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IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer

Bibliographic Details
Main Author: Couto, Nuno
Publication Date: 2022
Other Authors: Elzanowska, Julia, Maia, Joana, Batista, Silvia, Pereira, Catarina Esteves, Beck, Hans Christian, Carvalho, Ana Sofia, Strano Moraes, Maria Carolina, Carvalho, Carlos, Oliveira, Manuela, Matthiesen, Rune, Costa-Silva, Bruno
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/144475
Summary: Funding Information: J.E. was supported by grant 765492 from H2020-MSCA-ITN-2017. J.M. was supported by “Fundação para a Ciência e a Tecnologia” (PD/BD/105866/2014). S.B. was supported by the EMBO Installation Grant 3921. This work was supported by the Champalimaud Foundation and grant LCF/PR/HR19/52160014 from “La Caixa” Foundation. M.O.’s research is partially supported by National Funds through FCT, Fundação para a Ciência e a Tecnologia, projects 343 UIDB/04674/2020 (CIMA) and H2020-MSCA-RISE-2020/101007950, with the title ”DecisionES—Decision Support for the Supply of Ecosystem Services under Global Change,” funded by the Marie Curie International Staff Exchange Scheme.
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spelling IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancerbiomarkerextracellular vesiclesIgGliquid biopsypancreatic cancerBiochemistry, Genetics and Molecular Biology(all)SDG 3 - Good Health and Well-beingFunding Information: J.E. was supported by grant 765492 from H2020-MSCA-ITN-2017. J.M. was supported by “Fundação para a Ciência e a Tecnologia” (PD/BD/105866/2014). S.B. was supported by the EMBO Installation Grant 3921. This work was supported by the Champalimaud Foundation and grant LCF/PR/HR19/52160014 from “La Caixa” Foundation. M.O.’s research is partially supported by National Funds through FCT, Fundação para a Ciência e a Tecnologia, projects 343 UIDB/04674/2020 (CIMA) and H2020-MSCA-RISE-2020/101007950, with the title ”DecisionES—Decision Support for the Supply of Ecosystem Services under Global Change,” funded by the Marie Curie International Staff Exchange Scheme.(1) Background: Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second-leading cause of cancer deaths by 2030. Imaging techniques are the standard for monitoring the therapy response in PDAC, but these techniques have considerable limits, including delayed disease progression detection and difficulty in distinguishing benign from malignant lesions. Extracellular vesicle (EV) liquid biopsy is an emerging diagnosis modality. Nonetheless, the majority of research for EV-based diagnosis relies on point analyses of EVs at specified times, while longitudinal EV population studies before and during therapeutic interventions remain largely unexplored. (2) Methods: We analyzed plasma EV protein composition at diagnosis and throughout PDAC therapy. (3) Results: We found that IgG is linked with the diagnosis of PDAC and the patient’s response to therapy, and that the IgG+ EV population increases with disease progression and reduces with treatment response. Importantly, this covers PDAC patients devoid of the standard PDAC seric marker CA19.9 expression. We also observed that IgG is bound to EVs via the tumor antigen MAGE B1, and that this is independent of the patient’s inflammatory condition and IgG seric levels. (4) Conclusions: We here propose that a population analysis of IgG+ EVs in PDAC plasma represents a novel method to supplement the monitoring of the PDAC treatment response.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCouto, NunoElzanowska, JuliaMaia, JoanaBatista, SilviaPereira, Catarina EstevesBeck, Hans ChristianCarvalho, Ana SofiaStrano Moraes, Maria CarolinaCarvalho, CarlosOliveira, ManuelaMatthiesen, RuneCosta-Silva, Bruno2022-10-04T22:15:36Z2022-092022-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/144475eng2073-4409PURE: 46890307https://doi.org/10.3390/cells11182800info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:05:47Zoai:run.unl.pt:10362/144475Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:36:14.655915Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
title IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
spellingShingle IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
Couto, Nuno
biomarker
extracellular vesicles
IgG
liquid biopsy
pancreatic cancer
Biochemistry, Genetics and Molecular Biology(all)
SDG 3 - Good Health and Well-being
title_short IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
title_full IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
title_fullStr IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
title_full_unstemmed IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
title_sort IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer
author Couto, Nuno
author_facet Couto, Nuno
Elzanowska, Julia
Maia, Joana
Batista, Silvia
Pereira, Catarina Esteves
Beck, Hans Christian
Carvalho, Ana Sofia
Strano Moraes, Maria Carolina
Carvalho, Carlos
Oliveira, Manuela
Matthiesen, Rune
Costa-Silva, Bruno
author_role author
author2 Elzanowska, Julia
Maia, Joana
Batista, Silvia
Pereira, Catarina Esteves
Beck, Hans Christian
Carvalho, Ana Sofia
Strano Moraes, Maria Carolina
Carvalho, Carlos
Oliveira, Manuela
Matthiesen, Rune
Costa-Silva, Bruno
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Couto, Nuno
Elzanowska, Julia
Maia, Joana
Batista, Silvia
Pereira, Catarina Esteves
Beck, Hans Christian
Carvalho, Ana Sofia
Strano Moraes, Maria Carolina
Carvalho, Carlos
Oliveira, Manuela
Matthiesen, Rune
Costa-Silva, Bruno
dc.subject.por.fl_str_mv biomarker
extracellular vesicles
IgG
liquid biopsy
pancreatic cancer
Biochemistry, Genetics and Molecular Biology(all)
SDG 3 - Good Health and Well-being
topic biomarker
extracellular vesicles
IgG
liquid biopsy
pancreatic cancer
Biochemistry, Genetics and Molecular Biology(all)
SDG 3 - Good Health and Well-being
description Funding Information: J.E. was supported by grant 765492 from H2020-MSCA-ITN-2017. J.M. was supported by “Fundação para a Ciência e a Tecnologia” (PD/BD/105866/2014). S.B. was supported by the EMBO Installation Grant 3921. This work was supported by the Champalimaud Foundation and grant LCF/PR/HR19/52160014 from “La Caixa” Foundation. M.O.’s research is partially supported by National Funds through FCT, Fundação para a Ciência e a Tecnologia, projects 343 UIDB/04674/2020 (CIMA) and H2020-MSCA-RISE-2020/101007950, with the title ”DecisionES—Decision Support for the Supply of Ecosystem Services under Global Change,” funded by the Marie Curie International Staff Exchange Scheme.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-04T22:15:36Z
2022-09
2022-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/144475
url http://hdl.handle.net/10362/144475
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4409
PURE: 46890307
https://doi.org/10.3390/cells11182800
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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