P-cadherin expression in breast cancer: a review

Bibliographic Details
Main Author: Paredes, Joana
Publication Date: 2007
Other Authors: Correia, Ana Luísa, Ribeiro, Ana Sofia, Albergaria, André, Milanezi, Maria Fernanda Grillo, Schmitt, Fernando C.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/67752
Summary: P-cadherin is frequently over-expressed in high-grade invasive breast carcinomas and has been reported to be an enhancer of migration and invasion of breast cancer cells, being correlated with tumour aggressiveness. In addition, expression of P-cadherin is well established as an indicator of poor prognosis in human breast cancer, which has stimulated our interest in studying its role in this setting. This review describes the most important findings on P-cadherin expression and function in normal mammary tissue and breast cancer cells, emphasizing that further research is required to elucidate the role played by this protein in human mammary tumours.
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spelling P-cadherin expression in breast cancer: a reviewAnimalsBreast NeoplasmsCadherinsHumansScience & TechnologyP-cadherin is frequently over-expressed in high-grade invasive breast carcinomas and has been reported to be an enhancer of migration and invasion of breast cancer cells, being correlated with tumour aggressiveness. In addition, expression of P-cadherin is well established as an indicator of poor prognosis in human breast cancer, which has stimulated our interest in studying its role in this setting. This review describes the most important findings on P-cadherin expression and function in normal mammary tissue and breast cancer cells, emphasizing that further research is required to elucidate the role played by this protein in human mammary tumours.The performance of this review was supported by four research grants (Joana Paredes: SFRH/BPD/15319/2005; André Albergaria: SFRH/ BD/15316/2005; Ana Sofia Ribeiro: POCI/BIA-BCM/59252/2004; and Ana Luísa Correia: POCI/N/07.01.02/10/25/2005) and by a scientific project (POCI/BIA-BCM/59252/2004), all financed by the Portuguese Science and Technology Foundation. We also give thanks to the Calouste Gulbenkian Foundation for the ‘Programa Gulbenkian de Estímulo à Investigação (FCG 55/05)’.BioMed Central (BMC)Universidade do MinhoParedes, JoanaCorreia, Ana LuísaRibeiro, Ana SofiaAlbergaria, AndréMilanezi, Maria Fernanda GrilloSchmitt, Fernando C.20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/67752eng1465-54111465-542X10.1186/bcr177418001487info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T06:24:20Zoai:repositorium.sdum.uminho.pt:1822/67752Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:52:23.388578Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv P-cadherin expression in breast cancer: a review
title P-cadherin expression in breast cancer: a review
spellingShingle P-cadherin expression in breast cancer: a review
Paredes, Joana
Animals
Breast Neoplasms
Cadherins
Humans
Science & Technology
title_short P-cadherin expression in breast cancer: a review
title_full P-cadherin expression in breast cancer: a review
title_fullStr P-cadherin expression in breast cancer: a review
title_full_unstemmed P-cadherin expression in breast cancer: a review
title_sort P-cadherin expression in breast cancer: a review
author Paredes, Joana
author_facet Paredes, Joana
Correia, Ana Luísa
Ribeiro, Ana Sofia
Albergaria, André
Milanezi, Maria Fernanda Grillo
Schmitt, Fernando C.
author_role author
author2 Correia, Ana Luísa
Ribeiro, Ana Sofia
Albergaria, André
Milanezi, Maria Fernanda Grillo
Schmitt, Fernando C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Paredes, Joana
Correia, Ana Luísa
Ribeiro, Ana Sofia
Albergaria, André
Milanezi, Maria Fernanda Grillo
Schmitt, Fernando C.
dc.subject.por.fl_str_mv Animals
Breast Neoplasms
Cadherins
Humans
Science & Technology
topic Animals
Breast Neoplasms
Cadherins
Humans
Science & Technology
description P-cadherin is frequently over-expressed in high-grade invasive breast carcinomas and has been reported to be an enhancer of migration and invasion of breast cancer cells, being correlated with tumour aggressiveness. In addition, expression of P-cadherin is well established as an indicator of poor prognosis in human breast cancer, which has stimulated our interest in studying its role in this setting. This review describes the most important findings on P-cadherin expression and function in normal mammary tissue and breast cancer cells, emphasizing that further research is required to elucidate the role played by this protein in human mammary tumours.
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/67752
url http://hdl.handle.net/1822/67752
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1465-5411
1465-542X
10.1186/bcr1774
18001487
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central (BMC)
publisher.none.fl_str_mv BioMed Central (BMC)
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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