Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article

Bibliographic Details
Main Author: Rodrigues, Tiago
Publication Date: 2017
Other Authors: Matafome, Paulo, Sereno, José, Almeida, José, Castelhano, João, Gamas, Luís, Neves, Christian, Gonçalves, Sónia, Carvalho, Catarina, Arslanagic, Amina, Wilcken, Elinor, Fonseca, Rita, Simões, Ilda, V Conde, Silvia, Castelo-Branco, Miguel, Seiça, Raquel
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/152348
Summary: This study was supported by Portuguese Foundation for Science and Technology (projectUID/NEU/04539/2013), QREN-COMPETE (project DoIT- Diamarker: a consortium for the discovery of novel biomarker in diabetes), POCI-01-0145-FEDER-007440 and by the Faculty of Medicine, University of Coimbra. T. R. and P. M. are supported by a PhD (SFRH/BD/101172/2014) and a Post-Doc Grant (SFRH/BPD/104881/2014). This study was granted by the Portuguese Society of Diabetology (Portuguese National Prize of Diabetes).
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spelling Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 articleGeneralSDG 3 - Good Health and Well-beingThis study was supported by Portuguese Foundation for Science and Technology (projectUID/NEU/04539/2013), QREN-COMPETE (project DoIT- Diamarker: a consortium for the discovery of novel biomarker in diabetes), POCI-01-0145-FEDER-007440 and by the Faculty of Medicine, University of Coimbra. T. R. and P. M. are supported by a PhD (SFRH/BD/101172/2014) and a Post-Doc Grant (SFRH/BPD/104881/2014). This study was granted by the Portuguese Society of Diabetology (Portuguese National Prize of Diabetes).Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. Animal models supplemented with methylglyoxal (MG), maintained with a high-fat diet (HFD) or both (HFDMG) were studied for periepididymal adipose (pEAT) tissue hypoxia and local and systemic insulin resistance. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was used to quantify blood flow in vivo, showing MG-induced reduction of pEAT blood flow. Increased adipocyte size and leptin secretion were observed only in rats feeding the high-fat diet, without the development of hypoxia. In turn, hypoxia was only observed when MG was combined (HFDMG group), being associated with impaired activation of the insulin receptor (Tyr1163), glucose intolerance and systemic and muscle insulin resistance. Accordingly, the adipose tissue angiogenic assay has shown decreased capillarization after dose-dependent MG exposure and glyoxalase-1 inhibition. Thus, glycation impairs adipose tissue capillarization and blood flow, hampering its expandability during a high-fat diet challenge and leading to hypoxia and insulin resistance. Such events have systemic repercussions in glucose metabolism and may lead to the onset of unhealthy obesity and progression to type 2 diabetes.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNRodrigues, TiagoMatafome, PauloSereno, JoséAlmeida, JoséCastelhano, JoãoGamas, LuísNeves, ChristianGonçalves, SóniaCarvalho, CatarinaArslanagic, AminaWilcken, ElinorFonseca, RitaSimões, IldaV Conde, SilviaCastelo-Branco, MiguelSeiça, Raquel2023-05-02T22:12:54Z2017-12-012017-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/152348eng2045-2322PURE: 59822630https://doi.org/10.1038/s41598-017-01730-3info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:40:47Zoai:run.unl.pt:10362/152348Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:41:26.780025Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
title Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
spellingShingle Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
Rodrigues, Tiago
General
SDG 3 - Good Health and Well-being
title_short Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
title_full Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
title_fullStr Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
title_full_unstemmed Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
title_sort Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article
author Rodrigues, Tiago
author_facet Rodrigues, Tiago
Matafome, Paulo
Sereno, José
Almeida, José
Castelhano, João
Gamas, Luís
Neves, Christian
Gonçalves, Sónia
Carvalho, Catarina
Arslanagic, Amina
Wilcken, Elinor
Fonseca, Rita
Simões, Ilda
V Conde, Silvia
Castelo-Branco, Miguel
Seiça, Raquel
author_role author
author2 Matafome, Paulo
Sereno, José
Almeida, José
Castelhano, João
Gamas, Luís
Neves, Christian
Gonçalves, Sónia
Carvalho, Catarina
Arslanagic, Amina
Wilcken, Elinor
Fonseca, Rita
Simões, Ilda
V Conde, Silvia
Castelo-Branco, Miguel
Seiça, Raquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Rodrigues, Tiago
Matafome, Paulo
Sereno, José
Almeida, José
Castelhano, João
Gamas, Luís
Neves, Christian
Gonçalves, Sónia
Carvalho, Catarina
Arslanagic, Amina
Wilcken, Elinor
Fonseca, Rita
Simões, Ilda
V Conde, Silvia
Castelo-Branco, Miguel
Seiça, Raquel
dc.subject.por.fl_str_mv General
SDG 3 - Good Health and Well-being
topic General
SDG 3 - Good Health and Well-being
description This study was supported by Portuguese Foundation for Science and Technology (projectUID/NEU/04539/2013), QREN-COMPETE (project DoIT- Diamarker: a consortium for the discovery of novel biomarker in diabetes), POCI-01-0145-FEDER-007440 and by the Faculty of Medicine, University of Coimbra. T. R. and P. M. are supported by a PhD (SFRH/BD/101172/2014) and a Post-Doc Grant (SFRH/BPD/104881/2014). This study was granted by the Portuguese Society of Diabetology (Portuguese National Prize of Diabetes).
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
2017-12-01T00:00:00Z
2023-05-02T22:12:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/152348
url http://hdl.handle.net/10362/152348
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 59822630
https://doi.org/10.1038/s41598-017-01730-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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