Potential programming of dopaminergic circuits by early life stress

Bibliographic Details
Main Author: Rodrigues, Ana João
Publication Date: 2011
Other Authors: Leão, Pedro, Carvalho, M., Almeida, O. F. X., Sousa, Nuno
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/16683
Summary: Stress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors.
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spelling Potential programming of dopaminergic circuits by early life stressProgrammingGlucocorticoidsDopamineMesolimbicMesocorticalNigrostriatalTuberoinfundibularAddictionDepressionAnxietyNucleus accumbensVentral tegmental areaScience & TechnologyStress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors.Fundação para a Ciência e a Tecnologia (FCT)CRESCENDO (EU Integrated Project FP6-018652)Institute for Social and Affective NeuroscienceSpringerUniversidade do MinhoRodrigues, Ana JoãoLeão, PedroCarvalho, M.Almeida, O. F. X.Sousa, Nuno20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/16683eng0033-315810.1007/s00213-010-2085-321088961http://www.springerlink.com/link-out/?id=3032&code=T76746772852T726info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T07:00:35Zoai:repositorium.sdum.uminho.pt:1822/16683Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:12:14.300968Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Potential programming of dopaminergic circuits by early life stress
title Potential programming of dopaminergic circuits by early life stress
spellingShingle Potential programming of dopaminergic circuits by early life stress
Rodrigues, Ana João
Programming
Glucocorticoids
Dopamine
Mesolimbic
Mesocortical
Nigrostriatal
Tuberoinfundibular
Addiction
Depression
Anxiety
Nucleus accumbens
Ventral tegmental area
Science & Technology
title_short Potential programming of dopaminergic circuits by early life stress
title_full Potential programming of dopaminergic circuits by early life stress
title_fullStr Potential programming of dopaminergic circuits by early life stress
title_full_unstemmed Potential programming of dopaminergic circuits by early life stress
title_sort Potential programming of dopaminergic circuits by early life stress
author Rodrigues, Ana João
author_facet Rodrigues, Ana João
Leão, Pedro
Carvalho, M.
Almeida, O. F. X.
Sousa, Nuno
author_role author
author2 Leão, Pedro
Carvalho, M.
Almeida, O. F. X.
Sousa, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Ana João
Leão, Pedro
Carvalho, M.
Almeida, O. F. X.
Sousa, Nuno
dc.subject.por.fl_str_mv Programming
Glucocorticoids
Dopamine
Mesolimbic
Mesocortical
Nigrostriatal
Tuberoinfundibular
Addiction
Depression
Anxiety
Nucleus accumbens
Ventral tegmental area
Science & Technology
topic Programming
Glucocorticoids
Dopamine
Mesolimbic
Mesocortical
Nigrostriatal
Tuberoinfundibular
Addiction
Depression
Anxiety
Nucleus accumbens
Ventral tegmental area
Science & Technology
description Stress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/16683
url http://hdl.handle.net/1822/16683
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0033-3158
10.1007/s00213-010-2085-3
21088961
http://www.springerlink.com/link-out/?id=3032&code=T76746772852T726
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595802361004032

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