Mapping Antimalarial Drug Resistance in Mozambique

Bibliographic Details
Main Author: Chaves, Celso Raul Silambo
Publication Date: 2024
Other Authors: da Silva, Clemente, Salamandane, Acácio, Nogueira, Fatima
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/178182
Summary: Funding Information: Fatima Nogueira (F.N.) was funded by Fundacao para a Ciencia e a Tecnologia (FCT) grant GHTMUID/04413/2020 and LA-REAL-LA/P/0117/2020. Clemente da Silva (C.d.S.) was funded by Instituto CAMOES (https://www.instituto-camoes.pt/) BOLSAS CAMOES, FUNDACAO MILLENNIUM BCP and Paroquia de Sao Nicolau-Lisboa. Publisher Copyright: © 2024 by the authors.
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spelling Mapping Antimalarial Drug Resistance in MozambiqueA Systematic Review of Plasmodium falciparum Genetic Markers Post-ACT Implementationartemisinin-based combination therapymalaria drug resistancemolecular markersMozambiquePlasmodium falciparumCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: Fatima Nogueira (F.N.) was funded by Fundacao para a Ciencia e a Tecnologia (FCT) grant GHTMUID/04413/2020 and LA-REAL-LA/P/0117/2020. Clemente da Silva (C.d.S.) was funded by Instituto CAMOES (https://www.instituto-camoes.pt/) BOLSAS CAMOES, FUNDACAO MILLENNIUM BCP and Paroquia de Sao Nicolau-Lisboa. Publisher Copyright: © 2024 by the authors.Malaria continues to be a significant public health burden in many tropical and subtropical regions. Mozambique ranks among the top countries affected by malaria, where it is a leading cause of morbidity and mortality, accounting for 29% of all hospital deaths in the general population and 42% of deaths amongst children under five. This review presents a comparative analysis of data on five critical genes associated with antimalarial drug resistance: pfmdr1, pfcrt, pfk13, pfdhfr, and pfdhps, along with the copy number variation (CNV) in genes pfmdr1 and pfpm2/3. These are genes associated with parasite response to antimalarials currently used to treat uncomplicated P. falciparum malaria in Mozambique. The review synthesizes data collected from published studies conducted in Mozambique after the introduction of artemisinin-based combination therapies (ACTs) (2006) up to June 2024, highlighting the presence or absence of mutations in these genes across Mozambique. We aimed at mapping the prevalence and distribution of these molecular markers across the country in order to contribute to the development of targeted interventions to sustain the efficacy of malaria treatments in Mozambique. Four databases were used to access the articles: PubMed, Science Direct, Scopus, and Google scholar. The search strategy identified 132 studies addressing malaria and antimalarial resistance. Of these, 112 were excluded for various reasons, leaving 20 studies to be included in this review. Children and pregnant women represent the majority of target groups in studies on all types of antimalarials. Most studies (87.5%) were conducted in the provinces of Maputo and Gaza. The primary alleles reported were pfcrt CVMNK, and in the most recent data, its wild-type form was found in the majority of patients. A low prevalence of mutations in the pfk13 gene was identified reflecting the effectiveness of ACTs. In pfk13, only mutation A578S was reported in Niassa and Tete. CNVs were observed in studies carried out in the south of Mozambique, with a frequency of 1.1–5.1% for pfmdr1 and a frequency of 1.1–3.4% for pfpm2. This review indicates that molecular markers linked to malaria resistance show considerable variation across provinces in Mozambique, with most up-to-date data accessible for Maputo and Gaza. In contrast, provinces such as Zambezia and Inhambane have limited data on several genes, while Nampula lacks data on all drug resistance markers.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Laboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)Vector borne diseases and pathogens (VBD)RUNChaves, Celso Raul Silamboda Silva, ClementeSalamandane, AcácioNogueira, Fatima2025-01-30T21:15:47Z2024-122024-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/178182eng1661-6596PURE: 108380922https://doi.org/10.3390/ijms252413645info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-31T01:54:42Zoai:run.unl.pt:10362/178182Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:46:18.493799Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Mapping Antimalarial Drug Resistance in Mozambique
A Systematic Review of Plasmodium falciparum Genetic Markers Post-ACT Implementation
title Mapping Antimalarial Drug Resistance in Mozambique
spellingShingle Mapping Antimalarial Drug Resistance in Mozambique
Chaves, Celso Raul Silambo
artemisinin-based combination therapy
malaria drug resistance
molecular markers
Mozambique
Plasmodium falciparum
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
title_short Mapping Antimalarial Drug Resistance in Mozambique
title_full Mapping Antimalarial Drug Resistance in Mozambique
title_fullStr Mapping Antimalarial Drug Resistance in Mozambique
title_full_unstemmed Mapping Antimalarial Drug Resistance in Mozambique
title_sort Mapping Antimalarial Drug Resistance in Mozambique
author Chaves, Celso Raul Silambo
author_facet Chaves, Celso Raul Silambo
da Silva, Clemente
Salamandane, Acácio
Nogueira, Fatima
author_role author
author2 da Silva, Clemente
Salamandane, Acácio
Nogueira, Fatima
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
Laboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv Chaves, Celso Raul Silambo
da Silva, Clemente
Salamandane, Acácio
Nogueira, Fatima
dc.subject.por.fl_str_mv artemisinin-based combination therapy
malaria drug resistance
molecular markers
Mozambique
Plasmodium falciparum
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
topic artemisinin-based combination therapy
malaria drug resistance
molecular markers
Mozambique
Plasmodium falciparum
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
description Funding Information: Fatima Nogueira (F.N.) was funded by Fundacao para a Ciencia e a Tecnologia (FCT) grant GHTMUID/04413/2020 and LA-REAL-LA/P/0117/2020. Clemente da Silva (C.d.S.) was funded by Instituto CAMOES (https://www.instituto-camoes.pt/) BOLSAS CAMOES, FUNDACAO MILLENNIUM BCP and Paroquia de Sao Nicolau-Lisboa. Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
2024-12-01T00:00:00Z
2025-01-30T21:15:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/178182
url http://hdl.handle.net/10362/178182
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 108380922
https://doi.org/10.3390/ijms252413645
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833598314221666304

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