Development of electrospun Ion jelly fibers® for drug delivery

Detalhes bibliográficos
Autor(a) principal: Santos, Renato Brito Moreira dos
Data de Publicação: 2011
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/6593
Resumo: Dissertação para obtenção do Grau de Mestre em Biotecnologia
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spelling Development of electrospun Ion jelly fibers® for drug deliveryIonic liquidsIon JellyElectrospinningActive pharmaceutical ingredientsDrug deliveryDissertação para obtenção do Grau de Mestre em BiotecnologiaThe aim of this work was the development of a drug delivery system based on Ion Jelly fibers. Ion Jelly (IJ) is a highly versatile polymeric material and is the result from the combination of gelatin and an ionic liquid (IL). For that purpose, different IJs were created using ILs based on choline and active pharmaceutical ingredients. The ILs used were choline acetate ([Ch][Ac]), choline mandelate([Ch][Ma]), choline tiglate ([Ch][Ti]) and choline ibuprofenate([Ch][Ib]). IJ fibers for drug delivery systems were produced through electrospinning, owing to its ability of producing polymeric fibers with reduced diameters and high surface area. The aim of this approach was to overcome the low diffusion rate that the above ILs exhibit due to their high viscosity. The impacts of electrospinning parameters on fiber production were evaluated. We verified that the most important parameter to achieve defect-free and thin IJ fibers was IL concentration. Morphological studies of IJ electrospun fibers were performed through optical microscopy and scanning electron microscopy. It was observed that IJ - [Ch][Ib] yielded slightly thinner fibers when compared with IJ-[Ch][Ti] fibers. The results from antibacterial tests using mandelic acid, [Ch][Ma] and IJ-[Ch][Ma] fibers as antibacterial agents against Escherichia coli K-12 and Bacillus subtilis T-168 prove that[Ch][Ma] encapsulation in IJ electrospun fibers greatly increased the IL properties. In addition,toxicological data suggest that the ILs studied were not toxic with the exception of [Ch][Ib] which shows a similar toxicity to crystalline ibuprofene. In addition, tensile tests suggest that water content has an important impact on both IJ mechanic behavior and elasticity. Additionally, we also evaluated the fabrication of IJ fibers using other polymers beyond gelatin, namely DNA and N,N-Dimethylchitosan. Nevertheless, no fibers were obtained.Faculdade de Ciências e TecnologiaGomes, PedroBorges, João PauloRUNSantos, Renato Brito Moreira dos2011-12-29T12:19:50Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/6593enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:09:46Zoai:run.unl.pt:10362/6593Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:40:40.637126Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Development of electrospun Ion jelly fibers® for drug delivery
title Development of electrospun Ion jelly fibers® for drug delivery
spellingShingle Development of electrospun Ion jelly fibers® for drug delivery
Santos, Renato Brito Moreira dos
Ionic liquids
Ion Jelly
Electrospinning
Active pharmaceutical ingredients
Drug delivery
title_short Development of electrospun Ion jelly fibers® for drug delivery
title_full Development of electrospun Ion jelly fibers® for drug delivery
title_fullStr Development of electrospun Ion jelly fibers® for drug delivery
title_full_unstemmed Development of electrospun Ion jelly fibers® for drug delivery
title_sort Development of electrospun Ion jelly fibers® for drug delivery
author Santos, Renato Brito Moreira dos
author_facet Santos, Renato Brito Moreira dos
author_role author
dc.contributor.none.fl_str_mv Gomes, Pedro
Borges, João Paulo
RUN
dc.contributor.author.fl_str_mv Santos, Renato Brito Moreira dos
dc.subject.por.fl_str_mv Ionic liquids
Ion Jelly
Electrospinning
Active pharmaceutical ingredients
Drug delivery
topic Ionic liquids
Ion Jelly
Electrospinning
Active pharmaceutical ingredients
Drug delivery
description Dissertação para obtenção do Grau de Mestre em Biotecnologia
publishDate 2011
dc.date.none.fl_str_mv 2011-12-29T12:19:50Z
2011
2011-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/6593
url http://hdl.handle.net/10362/6593
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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