E-cadherin deregulation in breast cancer

Bibliographic Details
Main Author: Corso, G
Publication Date: 2020
Other Authors: Figueiredo, J, Angelis, SP, Corso, F, Girardi, A, Pereira, J, Seruca, R, Bonanni, B, Carneiro, P, Pravettoni, G, Guerini Rocco, E, Veronesi, P, Montagna, G, Sacchini, V, Gandini, S
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10216/142516
Summary: E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
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spelling E-cadherin deregulation in breast cancerE-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.Wiley20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/142516eng1582-183810.1111/jcmm.15140Corso, GFigueiredo, JAngelis, SPCorso, FGirardi, APereira, JSeruca, RBonanni, BCarneiro, PPravettoni, GGuerini Rocco, EVeronesi, PMontagna, GSacchini, VGandini, Sinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T20:04:06Zoai:repositorio-aberto.up.pt:10216/142516Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T23:47:56.572688Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv E-cadherin deregulation in breast cancer
title E-cadherin deregulation in breast cancer
spellingShingle E-cadherin deregulation in breast cancer
Corso, G
title_short E-cadherin deregulation in breast cancer
title_full E-cadherin deregulation in breast cancer
title_fullStr E-cadherin deregulation in breast cancer
title_full_unstemmed E-cadherin deregulation in breast cancer
title_sort E-cadherin deregulation in breast cancer
author Corso, G
author_facet Corso, G
Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
author_role author
author2 Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Corso, G
Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
description E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/142516
url https://hdl.handle.net/10216/142516
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1582-1838
10.1111/jcmm.15140
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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