The role of extracellular vesicles during CNS development

Bibliographic Details
Main Author: Bahram Sangani, Nasim
Publication Date: 2021
Other Authors: Gomes, Ana Rita, Curfs, Leopold M.G., Reutelingsperger, Chris P.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/49849
Summary: © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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spelling The role of extracellular vesicles during CNS developmentCNS developmentExosomesExtracellular vesiclesIntracellular communicationGliaNeuron© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)With a diverse set of neuronal and glial cell populations, Central Nervous System (CNS) has one of the most complex structures in the body. Intercellular communication is therefore highly important to coordinate cell-to-cell interactions. Besides electrical and chemical messengers, CNS cells also benefit from another communication route, what is known as extracellular vesicles, to harmonize their interactions. Extracellular Vesicles (EVs) and their subtype exosomes are membranous particles secreted by cells and contain information packaged in the form of biomolecules such as small fragments of DNA, lipids, miRNAs, mRNAs, and proteins. They are able to efficiently drive changes upon their arrival to recipient cells. EVs actively participate in all stages of CNS development by stimulating neural cell proliferation, differentiation, synaptic formation, and mediating reciprocal interactions between neurons and oligodendrocyte for myelination process. The aim of the present review is to enlighten the presence and contribution of EVs at each CNS developmental milestone.ElsevierRepositório da Universidade de LisboaBahram Sangani, NasimGomes, Ana RitaCurfs, Leopold M.G.Reutelingsperger, Chris P.2021-10-11T13:59:19Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49849engProg Neurobiol. 2021 Oct;205:102124.0301-008210.1016/j.pneurobio.2021.1021241873-5118info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:37:42Zoai:repositorio.ulisboa.pt:10451/49849Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:18:11.839304Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The role of extracellular vesicles during CNS development
title The role of extracellular vesicles during CNS development
spellingShingle The role of extracellular vesicles during CNS development
Bahram Sangani, Nasim
CNS development
Exosomes
Extracellular vesicles
Intracellular communication
Glia
Neuron
title_short The role of extracellular vesicles during CNS development
title_full The role of extracellular vesicles during CNS development
title_fullStr The role of extracellular vesicles during CNS development
title_full_unstemmed The role of extracellular vesicles during CNS development
title_sort The role of extracellular vesicles during CNS development
author Bahram Sangani, Nasim
author_facet Bahram Sangani, Nasim
Gomes, Ana Rita
Curfs, Leopold M.G.
Reutelingsperger, Chris P.
author_role author
author2 Gomes, Ana Rita
Curfs, Leopold M.G.
Reutelingsperger, Chris P.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bahram Sangani, Nasim
Gomes, Ana Rita
Curfs, Leopold M.G.
Reutelingsperger, Chris P.
dc.subject.por.fl_str_mv CNS development
Exosomes
Extracellular vesicles
Intracellular communication
Glia
Neuron
topic CNS development
Exosomes
Extracellular vesicles
Intracellular communication
Glia
Neuron
description © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
publishDate 2021
dc.date.none.fl_str_mv 2021-10-11T13:59:19Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49849
url http://hdl.handle.net/10451/49849
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Prog Neurobiol. 2021 Oct;205:102124.
0301-0082
10.1016/j.pneurobio.2021.102124
1873-5118
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601655953686528

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