Targeting the bone marrow niche, moving towards leukemia eradication

Bibliographic Details
Main Author: Semedo, Carla
Publication Date: 2024
Other Authors: Caroço, Raquel, Almeida, António, Cardoso, Bruno António
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.14/52779
Summary: Hematopoiesis is a complex and tightly regulated process that drives the formation of mature blood cells from a single hematopoietic stem cell. This complex process occurs within the bone marrow, which, once disrupted or deregulated, subverts normal hematopoietic development, allowing leukemic cells to emerge, proliferate, and thrive. Notably, several cellular populations and paracrine factors within the bone marrow fuel leukemia expansion and progression. This review presents an overview of the main microenvironmental components that promote myeloid leukemia progression, discussing the emerging therapeutical strategies that target both leukemic cells and the supportive bone marrow microenvironment – targeting both the seed and the soil.
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spelling Targeting the bone marrow niche, moving towards leukemia eradicationBone marrow microenvironmentBone marrow targetingHematopoiesisLeukemiaMyeloid neoplasiaHematopoiesis is a complex and tightly regulated process that drives the formation of mature blood cells from a single hematopoietic stem cell. This complex process occurs within the bone marrow, which, once disrupted or deregulated, subverts normal hematopoietic development, allowing leukemic cells to emerge, proliferate, and thrive. Notably, several cellular populations and paracrine factors within the bone marrow fuel leukemia expansion and progression. This review presents an overview of the main microenvironmental components that promote myeloid leukemia progression, discussing the emerging therapeutical strategies that target both leukemic cells and the supportive bone marrow microenvironment – targeting both the seed and the soil.VeritatiSemedo, CarlaCaroço, RaquelAlmeida, AntónioCardoso, Bruno António2025-03-19T09:37:37Z2024-07-222024-07-22T00:00:00Zresearch articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10400.14/52779eng2813-393510.3389/frhem.2024.1429916info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-25T01:41:48Zoai:repositorio.ucp.pt:10400.14/52779Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:39:35.151983Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Targeting the bone marrow niche, moving towards leukemia eradication
title Targeting the bone marrow niche, moving towards leukemia eradication
spellingShingle Targeting the bone marrow niche, moving towards leukemia eradication
Semedo, Carla
Bone marrow microenvironment
Bone marrow targeting
Hematopoiesis
Leukemia
Myeloid neoplasia
title_short Targeting the bone marrow niche, moving towards leukemia eradication
title_full Targeting the bone marrow niche, moving towards leukemia eradication
title_fullStr Targeting the bone marrow niche, moving towards leukemia eradication
title_full_unstemmed Targeting the bone marrow niche, moving towards leukemia eradication
title_sort Targeting the bone marrow niche, moving towards leukemia eradication
author Semedo, Carla
author_facet Semedo, Carla
Caroço, Raquel
Almeida, António
Cardoso, Bruno António
author_role author
author2 Caroço, Raquel
Almeida, António
Cardoso, Bruno António
author2_role author
author
author
dc.contributor.none.fl_str_mv Veritati
dc.contributor.author.fl_str_mv Semedo, Carla
Caroço, Raquel
Almeida, António
Cardoso, Bruno António
dc.subject.por.fl_str_mv Bone marrow microenvironment
Bone marrow targeting
Hematopoiesis
Leukemia
Myeloid neoplasia
topic Bone marrow microenvironment
Bone marrow targeting
Hematopoiesis
Leukemia
Myeloid neoplasia
description Hematopoiesis is a complex and tightly regulated process that drives the formation of mature blood cells from a single hematopoietic stem cell. This complex process occurs within the bone marrow, which, once disrupted or deregulated, subverts normal hematopoietic development, allowing leukemic cells to emerge, proliferate, and thrive. Notably, several cellular populations and paracrine factors within the bone marrow fuel leukemia expansion and progression. This review presents an overview of the main microenvironmental components that promote myeloid leukemia progression, discussing the emerging therapeutical strategies that target both leukemic cells and the supportive bone marrow microenvironment – targeting both the seed and the soil.
publishDate 2024
dc.date.none.fl_str_mv 2024-07-22
2024-07-22T00:00:00Z
2025-03-19T09:37:37Z
dc.type.driver.fl_str_mv research article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/52779
url http://hdl.handle.net/10400.14/52779
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2813-3935
10.3389/frhem.2024.1429916
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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