Exportação concluída — 

Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Oscar F.
Data de Publicação: 2017
Outros Autores: Sousa, Sónia, Carvalho, Sandra, Leite, Jorge, Ganho, Ana, Fernandes-Gonçalves, Ana, Pocinho, Fernando, Carracedo, Angel, Sampaio, Adriana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/10316/93301
https://doi.org/10.7334/psicothema2016.86
Resumo: Background: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in corticostriatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporalparietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as diffi culties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial defi cits (superior parietal lobe).
id RCAP_d619ab82ec38ecf4df3c0abb30b00b0e
oai_identifier_str oai:estudogeral.uc.pt:10316/93301
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivoObsessive-compulsive disorderGray matterWhite matterVoxel based morphometryBackground: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in corticostriatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporalparietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as diffi culties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial defi cits (superior parietal lobe).2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/93301https://hdl.handle.net/10316/93301https://doi.org/10.7334/psicothema2016.86eng0214 - 9915Gonçalves, Oscar F.Sousa, SóniaCarvalho, SandraLeite, JorgeGanho, AnaFernandes-Gonçalves, AnaPocinho, FernandoCarracedo, AngelSampaio, Adrianainfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2022-05-25T06:48:35Zoai:estudogeral.uc.pt:10316/93301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:40:58.911954Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
title Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
spellingShingle Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
Gonçalves, Oscar F.
Obsessive-compulsive disorder
Gray matter
White matter
Voxel based morphometry
title_short Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
title_full Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
title_fullStr Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
title_full_unstemmed Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
title_sort Alterations of gray and white matter morphology in obsessive compulsive disorder | Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
author Gonçalves, Oscar F.
author_facet Gonçalves, Oscar F.
Sousa, Sónia
Carvalho, Sandra
Leite, Jorge
Ganho, Ana
Fernandes-Gonçalves, Ana
Pocinho, Fernando
Carracedo, Angel
Sampaio, Adriana
author_role author
author2 Sousa, Sónia
Carvalho, Sandra
Leite, Jorge
Ganho, Ana
Fernandes-Gonçalves, Ana
Pocinho, Fernando
Carracedo, Angel
Sampaio, Adriana
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Oscar F.
Sousa, Sónia
Carvalho, Sandra
Leite, Jorge
Ganho, Ana
Fernandes-Gonçalves, Ana
Pocinho, Fernando
Carracedo, Angel
Sampaio, Adriana
dc.subject.por.fl_str_mv Obsessive-compulsive disorder
Gray matter
White matter
Voxel based morphometry
topic Obsessive-compulsive disorder
Gray matter
White matter
Voxel based morphometry
description Background: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in corticostriatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporalparietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as diffi culties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial defi cits (superior parietal lobe).
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/93301
https://hdl.handle.net/10316/93301
https://doi.org/10.7334/psicothema2016.86
url https://hdl.handle.net/10316/93301
https://doi.org/10.7334/psicothema2016.86
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0214 - 9915
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602436535681024

Registros relacionados