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Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation

Bibliographic Details
Main Author: Jennifer Noro
Publication Date: 2017
Other Authors: Loureiro, Ana Isabel Sá, Gonçalves, Filipa D., Azóia, Nuno G., Jung, Seunho, Silva, Carla, Cavaco-Paulo, Artur
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/47808
Summary: New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.
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spelling Oil-based cyclo-oligosaccharide nanodevices for drug encapsulationCyclo-oligosaccharidescyclosophoraosepalmitoyl chloridephase-changenanoemulsionsultrasoundScience & TechnologyNew encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.ERDF -European Regional Development Fundinfo:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoJennifer NoroLoureiro, Ana Isabel SáGonçalves, Filipa D.Azóia, Nuno G.Jung, SeunhoSilva, CarlaCavaco-Paulo, Artur2017-112017-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/47808engJennifer Noro; Loureiro, Ana; Gonçalves, Filipa D.; Azoia, Nuno G.; Jung, Seunho; Silva, Carla; Cavaco-Paulo, Artur, Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation. Colloids and Surfaces B: Biointerfaces, 159, 259-267, 2017092777650927-776510.1016/j.colsurfb.2017.07.05528800465http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T03:54:03Zoai:repositorium.sdum.uminho.pt:1822/47808Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:44:58.777759Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
spellingShingle Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
Jennifer Noro
Cyclo-oligosaccharides
cyclosophoraose
palmitoyl chloride
phase-change
nanoemulsions
ultrasound
Science & Technology
title_short Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_full Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_fullStr Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_full_unstemmed Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
title_sort Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation
author Jennifer Noro
author_facet Jennifer Noro
Loureiro, Ana Isabel Sá
Gonçalves, Filipa D.
Azóia, Nuno G.
Jung, Seunho
Silva, Carla
Cavaco-Paulo, Artur
author_role author
author2 Loureiro, Ana Isabel Sá
Gonçalves, Filipa D.
Azóia, Nuno G.
Jung, Seunho
Silva, Carla
Cavaco-Paulo, Artur
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Jennifer Noro
Loureiro, Ana Isabel Sá
Gonçalves, Filipa D.
Azóia, Nuno G.
Jung, Seunho
Silva, Carla
Cavaco-Paulo, Artur
dc.subject.por.fl_str_mv Cyclo-oligosaccharides
cyclosophoraose
palmitoyl chloride
phase-change
nanoemulsions
ultrasound
Science & Technology
topic Cyclo-oligosaccharides
cyclosophoraose
palmitoyl chloride
phase-change
nanoemulsions
ultrasound
Science & Technology
description New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
2017-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/47808
url https://hdl.handle.net/1822/47808
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jennifer Noro; Loureiro, Ana; Gonçalves, Filipa D.; Azoia, Nuno G.; Jung, Seunho; Silva, Carla; Cavaco-Paulo, Artur, Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation. Colloids and Surfaces B: Biointerfaces, 159, 259-267, 2017
09277765
0927-7765
10.1016/j.colsurfb.2017.07.055
28800465
http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594862451032064

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