Digital microfluidics for nucleic acid amplification
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Outros |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | https://doi.org/10.3390/s17071495 |
Resumo: | This work was funded by FEDER funds through the COMPETE 2020 Program (POCI-01-0145-FEDER-007728). BV thanks SFRH/BPD/124311/2016. PVB thanksWater JPI Proj TRACE (Ref 281715). |
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Digital microfluidics for nucleic acid amplificationDigital microfluidicsNucleic acid amplificationPoint-of-care diagnosticsAnalytical ChemistryAtomic and Molecular Physics, and OpticsBiochemistryInstrumentationElectrical and Electronic EngineeringSDG 3 - Good Health and Well-beingThis work was funded by FEDER funds through the COMPETE 2020 Program (POCI-01-0145-FEDER-007728). BV thanks SFRH/BPD/124311/2016. PVB thanksWater JPI Proj TRACE (Ref 281715).Digital Microfluidics (DMF) has emerged as a disruptive methodology for the control and manipulation of low volume droplets. In DMF, each droplet acts as a single reactor, which allows for extensive multiparallelization of biological and chemical reactions at a much smaller scale. DMF devices open entirely new and promising pathways for multiplex analysis and reaction occurring in a miniaturized format, thus allowing for healthcare decentralization from major laboratories to point-of-care with accurate, robust and inexpensive molecular diagnostics. Here, we shall focus on DMF platforms specifically designed for nucleic acid amplification, which is key for molecular diagnostics of several diseases and conditions, from pathogen identification to cancer mutations detection. Particular attention will be given to the device architecture, materials and nucleic acid amplification applications in validated settings.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNCoelho, BeatrizVeigas, BrunoFortunato, ElviraMartins, RodrigoÁguas, HugoIgreja, RuiBaptista, Pedro V.2019-03-12T23:17:08Z2017-07-012017-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://doi.org/10.3390/s17071495eng1424-8220PURE: 11472116http://www.scopus.com/inward/record.url?scp=85021393536&partnerID=8YFLogxKhttps://doi.org/10.3390/s17071495info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:37:43Zoai:run.unl.pt:10362/63112Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:08:38.717684Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Digital microfluidics for nucleic acid amplification |
| title |
Digital microfluidics for nucleic acid amplification |
| spellingShingle |
Digital microfluidics for nucleic acid amplification Coelho, Beatriz Digital microfluidics Nucleic acid amplification Point-of-care diagnostics Analytical Chemistry Atomic and Molecular Physics, and Optics Biochemistry Instrumentation Electrical and Electronic Engineering SDG 3 - Good Health and Well-being |
| title_short |
Digital microfluidics for nucleic acid amplification |
| title_full |
Digital microfluidics for nucleic acid amplification |
| title_fullStr |
Digital microfluidics for nucleic acid amplification |
| title_full_unstemmed |
Digital microfluidics for nucleic acid amplification |
| title_sort |
Digital microfluidics for nucleic acid amplification |
| author |
Coelho, Beatriz |
| author_facet |
Coelho, Beatriz Veigas, Bruno Fortunato, Elvira Martins, Rodrigo Águas, Hugo Igreja, Rui Baptista, Pedro V. |
| author_role |
author |
| author2 |
Veigas, Bruno Fortunato, Elvira Martins, Rodrigo Águas, Hugo Igreja, Rui Baptista, Pedro V. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
DCM - Departamento de Ciência dos Materiais CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida RUN |
| dc.contributor.author.fl_str_mv |
Coelho, Beatriz Veigas, Bruno Fortunato, Elvira Martins, Rodrigo Águas, Hugo Igreja, Rui Baptista, Pedro V. |
| dc.subject.por.fl_str_mv |
Digital microfluidics Nucleic acid amplification Point-of-care diagnostics Analytical Chemistry Atomic and Molecular Physics, and Optics Biochemistry Instrumentation Electrical and Electronic Engineering SDG 3 - Good Health and Well-being |
| topic |
Digital microfluidics Nucleic acid amplification Point-of-care diagnostics Analytical Chemistry Atomic and Molecular Physics, and Optics Biochemistry Instrumentation Electrical and Electronic Engineering SDG 3 - Good Health and Well-being |
| description |
This work was funded by FEDER funds through the COMPETE 2020 Program (POCI-01-0145-FEDER-007728). BV thanks SFRH/BPD/124311/2016. PVB thanksWater JPI Proj TRACE (Ref 281715). |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-07-01 2017-07-01T00:00:00Z 2019-03-12T23:17:08Z |
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info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/other |
| format |
other |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://doi.org/10.3390/s17071495 |
| url |
https://doi.org/10.3390/s17071495 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1424-8220 PURE: 11472116 http://www.scopus.com/inward/record.url?scp=85021393536&partnerID=8YFLogxK https://doi.org/10.3390/s17071495 |
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openAccess |
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application/pdf |
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