Update on biomarkers associated to cardioembolic stroke: a narrative review

Bibliographic Details
Main Author: Fonseca, Ana Catarina
Publication Date: 2021
Other Authors: Coelho, Pedro
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/49057
Summary: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Update on biomarkers associated to cardioembolic stroke: a narrative reviewBiomarkerCardioembolismStrokeAtrial fibrillationPatent foramen ovaleAtrial cardiomyopathyNT-proBNPBNPANP© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Background: In the last years, several studies were conducted that evaluated biomarkers that could be helpful for cardioembolic stroke diagnosis, prognosis, and the determination of risk of stroke recurrence. Methods: We performed a narrative review of the main studies that evaluated biomarkers related to specific cardioembolic causes: atrial fibrillation, patent foramen ovale, atrial cardiomyopathy, and left ventricular wall motion abnormalities. Results: BNP and NT-proBNP are, among all biomarkers of cardioembolic stroke, the ones that have the highest amount of evidence for their use. NT-proBNP is currently used for the selection of patients that will be included in clinical trials that aim to evaluate the use of anticoagulation in patients suspected of having a cardioembolic stroke and for the selection of patients to undergo cardiac monitoring. NT-proBNP has also been incorporated in tools used to predict the risk of stroke recurrence (ABC-stroke score). Conclusions: NT-proBNP and BNP continue to be the biomarkers most widely studied in the context of cardioembolic stroke. The possibility of using other biomarkers in clinical practice is still distant, mainly because of the low methodological quality of the studies in which they were evaluated. Both internal and external validation studies are rarely performed for most biomarkers.MDPIRepositório da Universidade de LisboaFonseca, Ana CatarinaCoelho, Pedro2021-07-22T13:10:19Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49057engLife (Basel). 2021 May 17;11(5):448.10.3390/life110504482075-1729info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:35:37Zoai:repositorio.ulisboa.pt:10451/49057Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:16:33.914650Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Update on biomarkers associated to cardioembolic stroke: a narrative review
title Update on biomarkers associated to cardioembolic stroke: a narrative review
spellingShingle Update on biomarkers associated to cardioembolic stroke: a narrative review
Fonseca, Ana Catarina
Biomarker
Cardioembolism
Stroke
Atrial fibrillation
Patent foramen ovale
Atrial cardiomyopathy
NT-proBNP
BNP
ANP
title_short Update on biomarkers associated to cardioembolic stroke: a narrative review
title_full Update on biomarkers associated to cardioembolic stroke: a narrative review
title_fullStr Update on biomarkers associated to cardioembolic stroke: a narrative review
title_full_unstemmed Update on biomarkers associated to cardioembolic stroke: a narrative review
title_sort Update on biomarkers associated to cardioembolic stroke: a narrative review
author Fonseca, Ana Catarina
author_facet Fonseca, Ana Catarina
Coelho, Pedro
author_role author
author2 Coelho, Pedro
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fonseca, Ana Catarina
Coelho, Pedro
dc.subject.por.fl_str_mv Biomarker
Cardioembolism
Stroke
Atrial fibrillation
Patent foramen ovale
Atrial cardiomyopathy
NT-proBNP
BNP
ANP
topic Biomarker
Cardioembolism
Stroke
Atrial fibrillation
Patent foramen ovale
Atrial cardiomyopathy
NT-proBNP
BNP
ANP
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-07-22T13:10:19Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49057
url http://hdl.handle.net/10451/49057
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Life (Basel). 2021 May 17;11(5):448.
10.3390/life11050448
2075-1729
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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