Interferon-gamma at the crossroads of tumor immune surveillance or evasion

Bibliographic Details
Main Author: Castro, Flávia
Publication Date: 2018
Other Authors: Cardoso, Ana Patrícia, Gonçalves, Raquel Madeira, Serre, Karine, Oliveira, Maria José
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/47057
Summary: Copyright © 2018 Castro, Cardoso, Gonçalves, Serre and Oliveira. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
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spelling Interferon-gamma at the crossroads of tumor immune surveillance or evasionCancer microenvironmentImmune contextureImmunoregulationImmunotherapyType II interferonCopyright © 2018 Castro, Cardoso, Gonçalves, Serre and Oliveira. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termsInterferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases, despite its adverse effects. Although broad evidence implicating IFN-γ in tumor immune surveillance, IFN-γ-based therapies undergoing clinical trials have been of limited success. In fact, recent reports suggested that it may also play a protumorigenic role, namely, through IFN-γ signaling insensitivity, downregulation of major histocompatibility complexes, and upregulation of indoleamine 2,3-dioxygenase and of checkpoint inhibitors, as programmed cell-death ligand 1. However, the IFN-γ-mediated responses are still positively associated with patient's survival in several cancers. Consequently, major research efforts are required to understand the immune contexture in which IFN-γ induces its intricate and highly regulated effects in the tumor microenvironment. This review discusses the current knowledge on the pro- and antitumorigenic effects of IFN-γ as part of the complex immune response to cancer, highlighting the relevance to identify IFN-γ responsive patients for the improvement of therapies that exploit associated signaling pathways.This article is a result of the project NORTE-01-0145-FEDER-000012, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and through the FCT PhD Programmes by Human Capital Operational Programme (POCH), specifically by the BiotechHealth Programme. FC and RG, KS, and MO also acknowledge FCT for PhD grant (PD/BD/114013/2015) and for the FCT Investigator Grants (IF/00638/2014, IF/00004/2014 and IF/01066/2012), respectively. AC has a postdoctoral fellowship (POCI-01-0145-FEDER-016390). KS received an iMM Laço-2016 research grant.FrontiersRepositório da Universidade de LisboaCastro, FláviaCardoso, Ana PatríciaGonçalves, Raquel MadeiraSerre, KarineOliveira, Maria José2021-03-25T12:37:51Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47057engFront Immunol. 2018 May 4;9:84710.3389/fimmu.2018.008471664-3224info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:30:28Zoai:repositorio.ulisboa.pt:10451/47057Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:14:01.290540Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Interferon-gamma at the crossroads of tumor immune surveillance or evasion
title Interferon-gamma at the crossroads of tumor immune surveillance or evasion
spellingShingle Interferon-gamma at the crossroads of tumor immune surveillance or evasion
Castro, Flávia
Cancer microenvironment
Immune contexture
Immunoregulation
Immunotherapy
Type II interferon
title_short Interferon-gamma at the crossroads of tumor immune surveillance or evasion
title_full Interferon-gamma at the crossroads of tumor immune surveillance or evasion
title_fullStr Interferon-gamma at the crossroads of tumor immune surveillance or evasion
title_full_unstemmed Interferon-gamma at the crossroads of tumor immune surveillance or evasion
title_sort Interferon-gamma at the crossroads of tumor immune surveillance or evasion
author Castro, Flávia
author_facet Castro, Flávia
Cardoso, Ana Patrícia
Gonçalves, Raquel Madeira
Serre, Karine
Oliveira, Maria José
author_role author
author2 Cardoso, Ana Patrícia
Gonçalves, Raquel Madeira
Serre, Karine
Oliveira, Maria José
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Castro, Flávia
Cardoso, Ana Patrícia
Gonçalves, Raquel Madeira
Serre, Karine
Oliveira, Maria José
dc.subject.por.fl_str_mv Cancer microenvironment
Immune contexture
Immunoregulation
Immunotherapy
Type II interferon
topic Cancer microenvironment
Immune contexture
Immunoregulation
Immunotherapy
Type II interferon
description Copyright © 2018 Castro, Cardoso, Gonçalves, Serre and Oliveira. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-03-25T12:37:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47057
url http://hdl.handle.net/10451/47057
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Immunol. 2018 May 4;9:847
10.3389/fimmu.2018.00847
1664-3224
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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