Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
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Publication Date: | 2022 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
Download full: | http://hdl.handle.net/10362/145600 |
Summary: | Principal Investigator contract IF/00915/2014 (T.C.), and a doctoral grant , a partnership from FCT/MCTES and the pharmaceutical company HOVIONE (R.V.). L.B.M. would like to acknowledge for FCT/MCTES funding with reference CEECIND/03810/2017. The NMR spectrometers in LabNMR@Cenimat are part of the National NMR Facility, supported by FCT (ROTEIRO/0031/2013 - PINFRA/22161/2016 ), co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC ( POCI-01-0145-FEDER-007688 ; UID/CTM/50025/2020-2023 ). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES ( UIDB/QUI/50006/2020 ) and cofunded by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007265 ). We also acknowledge Dr. Luz Fernandes, REQUIMTE analytical services, for GC analysis. Publisher Copyright: © 2022 |
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Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processesArtificial enzymesCatalysisGreen chemistryMolecular recognitionMolecularly imprinted polymersTEMPOCatalysisChemistry(all)Process Chemistry and TechnologyPrincipal Investigator contract IF/00915/2014 (T.C.), and a doctoral grant , a partnership from FCT/MCTES and the pharmaceutical company HOVIONE (R.V.). L.B.M. would like to acknowledge for FCT/MCTES funding with reference CEECIND/03810/2017. The NMR spectrometers in LabNMR@Cenimat are part of the National NMR Facility, supported by FCT (ROTEIRO/0031/2013 - PINFRA/22161/2016 ), co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC ( POCI-01-0145-FEDER-007688 ; UID/CTM/50025/2020-2023 ). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES ( UIDB/QUI/50006/2020 ) and cofunded by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007265 ). We also acknowledge Dr. Luz Fernandes, REQUIMTE analytical services, for GC analysis. Publisher Copyright: © 2022Catalysis in pharma manufacturing processes is typically homogeneous, expensive and with hard catalyst recovery/regeneration. Herein an enzyme-inspired dry-powder molecularly imprinted polymeric (MIP) system was designed for fast, selective oxidation of a cholesterol derivative and easy catalyst regeneration. The strategy involved the synthesis of a template-monomer (T:M) complex followed by the crosslinked polymerization in supercritical carbon dioxide (scCO2). A 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-MIP catalyst is obtained after the template cleavage from the matrix, and the oxidation of the N[sbnd]H groups turns available TEMPO moieties within the MIP. The oxidation of benzyl alcohol, 5α-cholestan-3β-ol and cholic acid was fast, in high yield and with selective oxidation capacity.LAQV@REQUIMTEDQ - Departamento de QuímicaDCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNViveiros, RaquelMaia, Luísa B.Corvo, Marta C.Bonifácio, Vasco D. B.Heggie, WilliamCasimiro, Teresa2022-11-17T22:13:18Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://hdl.handle.net/10362/145600eng1566-7367PURE: 47408938https://doi.org/10.1016/j.catcom.2022.106537info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:06:46Zoai:run.unl.pt:10362/145600Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:37:14.868778Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
dc.title.none.fl_str_mv |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes |
title |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes |
spellingShingle |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes Viveiros, Raquel Artificial enzymes Catalysis Green chemistry Molecular recognition Molecularly imprinted polymers TEMPO Catalysis Chemistry(all) Process Chemistry and Technology |
title_short |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes |
title_full |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes |
title_fullStr |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes |
title_full_unstemmed |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes |
title_sort |
Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes |
author |
Viveiros, Raquel |
author_facet |
Viveiros, Raquel Maia, Luísa B. Corvo, Marta C. Bonifácio, Vasco D. B. Heggie, William Casimiro, Teresa |
author_role |
author |
author2 |
Maia, Luísa B. Corvo, Marta C. Bonifácio, Vasco D. B. Heggie, William Casimiro, Teresa |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química DCM - Departamento de Ciência dos Materiais CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) RUN |
dc.contributor.author.fl_str_mv |
Viveiros, Raquel Maia, Luísa B. Corvo, Marta C. Bonifácio, Vasco D. B. Heggie, William Casimiro, Teresa |
dc.subject.por.fl_str_mv |
Artificial enzymes Catalysis Green chemistry Molecular recognition Molecularly imprinted polymers TEMPO Catalysis Chemistry(all) Process Chemistry and Technology |
topic |
Artificial enzymes Catalysis Green chemistry Molecular recognition Molecularly imprinted polymers TEMPO Catalysis Chemistry(all) Process Chemistry and Technology |
description |
Principal Investigator contract IF/00915/2014 (T.C.), and a doctoral grant , a partnership from FCT/MCTES and the pharmaceutical company HOVIONE (R.V.). L.B.M. would like to acknowledge for FCT/MCTES funding with reference CEECIND/03810/2017. The NMR spectrometers in LabNMR@Cenimat are part of the National NMR Facility, supported by FCT (ROTEIRO/0031/2013 - PINFRA/22161/2016 ), co-financed by FEDER through COMPETE 2020, POCI, and PORL and FCT through PIDDAC ( POCI-01-0145-FEDER-007688 ; UID/CTM/50025/2020-2023 ). The Associate Laboratory Research Unit for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES ( UIDB/QUI/50006/2020 ) and cofunded by the ERDF under the PT2020 Partnership Agreement ( POCI-01-0145-FEDER-007265 ). We also acknowledge Dr. Luz Fernandes, REQUIMTE analytical services, for GC analysis. Publisher Copyright: © 2022 |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-17T22:13:18Z 2022-12 2022-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/10362/145600 |
url |
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dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.none.fl_str_mv |
1566-7367 PURE: 47408938 https://doi.org/10.1016/j.catcom.2022.106537 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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7 application/pdf |
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