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Assessing T-lymphocyte activation by non-conventional metabolomics

Bibliographic Details
Main Author: Ramalhete, Luís
Publication Date: 2019
Other Authors: Calado, Cecília, Sancho, M. Rosário
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.21/14412
Summary: The current methodologies to evaluate T-cell function are based on very laborious or/and expensive methods. Nevertheless, the assessment of the appropriate functioning of these cells is very important in the clinical context, namely as a diagnostic tool of T-cell alloreactivity in different hematological settings, solid organ transplantation and immunosuppressive therapy. In the present work, we evaluated the potential of Non-conventional Metabolomics (NM) based on FTIR spectroscopy, in the assessment of T lymphocyte function after mitogen activation by phytohemagglutinin (PHa).
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spelling Assessing T-lymphocyte activation by non-conventional metabolomicsNon-conventional Metabolomics (NM)FTIR spectroscopyT lymphocytePhytohemagglutinin (PHa)The current methodologies to evaluate T-cell function are based on very laborious or/and expensive methods. Nevertheless, the assessment of the appropriate functioning of these cells is very important in the clinical context, namely as a diagnostic tool of T-cell alloreactivity in different hematological settings, solid organ transplantation and immunosuppressive therapy. In the present work, we evaluated the potential of Non-conventional Metabolomics (NM) based on FTIR spectroscopy, in the assessment of T lymphocyte function after mitogen activation by phytohemagglutinin (PHa).WileyRCIPLRamalhete, LuísCalado, CecíliaSancho, M. Rosário2022-03-09T07:55:01Z2019-052019-05-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10400.21/14412eng10.1111/tan.13511info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-12T09:55:03Zoai:repositorio.ipl.pt:10400.21/14412Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T20:03:37.869723Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Assessing T-lymphocyte activation by non-conventional metabolomics
title Assessing T-lymphocyte activation by non-conventional metabolomics
spellingShingle Assessing T-lymphocyte activation by non-conventional metabolomics
Ramalhete, Luís
Non-conventional Metabolomics (NM)
FTIR spectroscopy
T lymphocyte
Phytohemagglutinin (PHa)
title_short Assessing T-lymphocyte activation by non-conventional metabolomics
title_full Assessing T-lymphocyte activation by non-conventional metabolomics
title_fullStr Assessing T-lymphocyte activation by non-conventional metabolomics
title_full_unstemmed Assessing T-lymphocyte activation by non-conventional metabolomics
title_sort Assessing T-lymphocyte activation by non-conventional metabolomics
author Ramalhete, Luís
author_facet Ramalhete, Luís
Calado, Cecília
Sancho, M. Rosário
author_role author
author2 Calado, Cecília
Sancho, M. Rosário
author2_role author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Ramalhete, Luís
Calado, Cecília
Sancho, M. Rosário
dc.subject.por.fl_str_mv Non-conventional Metabolomics (NM)
FTIR spectroscopy
T lymphocyte
Phytohemagglutinin (PHa)
topic Non-conventional Metabolomics (NM)
FTIR spectroscopy
T lymphocyte
Phytohemagglutinin (PHa)
description The current methodologies to evaluate T-cell function are based on very laborious or/and expensive methods. Nevertheless, the assessment of the appropriate functioning of these cells is very important in the clinical context, namely as a diagnostic tool of T-cell alloreactivity in different hematological settings, solid organ transplantation and immunosuppressive therapy. In the present work, we evaluated the potential of Non-conventional Metabolomics (NM) based on FTIR spectroscopy, in the assessment of T lymphocyte function after mitogen activation by phytohemagglutinin (PHa).
publishDate 2019
dc.date.none.fl_str_mv 2019-05
2019-05-01T00:00:00Z
2022-03-09T07:55:01Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14412
url http://hdl.handle.net/10400.21/14412
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1111/tan.13511
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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