Pregnancy and its role in breast cancer

Bibliographic Details
Main Author: Martins, FC
Publication Date: 2008
Other Authors: Botelho, MF, Laranjo, M, Cabrita, AM, Torgal, MI, Oliveira, CF
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.4/127
Summary: Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.
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spelling Pregnancy and its role in breast cancerGravidezNeoplasias da MamaEarly full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.SpringerRIHUCMartins, FCBotelho, MFLaranjo, MCabrita, AMTorgal, MIOliveira, CF2008-11-24T16:10:57Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/127eng1970-5565info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-01-30T03:19:40Zoai:rihuc.huc.min-saude.pt:10400.4/127Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:43:03.692590Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Pregnancy and its role in breast cancer
title Pregnancy and its role in breast cancer
spellingShingle Pregnancy and its role in breast cancer
Martins, FC
Gravidez
Neoplasias da Mama
title_short Pregnancy and its role in breast cancer
title_full Pregnancy and its role in breast cancer
title_fullStr Pregnancy and its role in breast cancer
title_full_unstemmed Pregnancy and its role in breast cancer
title_sort Pregnancy and its role in breast cancer
author Martins, FC
author_facet Martins, FC
Botelho, MF
Laranjo, M
Cabrita, AM
Torgal, MI
Oliveira, CF
author_role author
author2 Botelho, MF
Laranjo, M
Cabrita, AM
Torgal, MI
Oliveira, CF
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Martins, FC
Botelho, MF
Laranjo, M
Cabrita, AM
Torgal, MI
Oliveira, CF
dc.subject.por.fl_str_mv Gravidez
Neoplasias da Mama
topic Gravidez
Neoplasias da Mama
description Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.
publishDate 2008
dc.date.none.fl_str_mv 2008-11-24T16:10:57Z
2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.4/127
url http://hdl.handle.net/10400.4/127
dc.language.iso.fl_str_mv eng
language eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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