Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles

Detalhes bibliográficos
Autor(a) principal: Cardoso, Maria Margarida
Data de Publicação: 2024
Outros Autores: Peça, Inês N., Bicho, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/174214
Resumo: The authors acknowledge the support from FCT/MCTES through the projects PTDC/EQU/EPR/119631/2010. The authors wish to thank the Analytical Services Laboratory of REQUIMTE for providing the DSC results. Publisher Copyright: © 2024 by the authors.
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spelling Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG NanoparticlesBaker–Lonsdale modeldoxorubicindrug-controlled releasenanoparticlesPLGAPLGA-PEG copolymersMaterials Science(all)Condensed Matter PhysicsSDG 3 - Good Health and Well-beingThe authors acknowledge the support from FCT/MCTES through the projects PTDC/EQU/EPR/119631/2010. The authors wish to thank the Analytical Services Laboratory of REQUIMTE for providing the DSC results. Publisher Copyright: © 2024 by the authors.Nanoparticles (NPs) have become attractive vehicles for drug delivery in cancer therapy due to their ability to accumulate in tumours and mitigate side effects. This study focuses on the production of doxorubicin (DOX)-loaded NPs comprising Poly (lactic-co-glycolic acid)-Polyethylene glycol with varying PEG proportions and the examination of their impact on drug release kinetics. DOX-loaded NPs, composed of PLGA-co-PEG with PEG contents of 0%, 5%, 10%, and 15%, were synthesized by the solvent evaporation technique, exhibited spherical morphology, and had sizes ranging from 420 nm to 690 nm. In vitro drug release studies revealed biphasic profiles, with higher PEG contents leading to faster and more extensive drug release. The Baker–Lonsdale model demonstrated the best fit to the drug release data, indicating that the release process is diffusion-controlled. The diffusion coefficients for DOX determined ranged from 6.3 × 10−18 to 7.55 × 10−17 cm2s−1 and exhibited an upward trend with increasing PEG content in the polymer. In vitro cytotoxicity tests with CHO cells showed that unloaded NPs are non-toxic, while DOX-loaded PLGA-PEG 15% NPs induced a greater decrease in cellular viability compared to their PLGA counterparts. A mathematical relationship between the diffusion coefficient and PEG percentage was derived, providing a practical tool for optimizing DOX release profiles.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNCardoso, Maria MargaridaPeça, Inês N.Bicho, Ana2024-10-29T00:37:52Z2024-07-172024-07-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/174214engCardoso, M. M., Peça, I. N., & Bicho, A. (2024). Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles. Materials, 17(14), Article 3544. https://doi.org/10.3390/ma171435441996-1944PURE: 101113409https://doi.org/10.3390/ma17143544info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-01-20T01:37:00Zoai:run.unl.pt:10362/174214Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:12:36.452815Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
title Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
spellingShingle Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
Cardoso, Maria Margarida
Baker–Lonsdale model
doxorubicin
drug-controlled release
nanoparticles
PLGA
PLGA-PEG copolymers
Materials Science(all)
Condensed Matter Physics
SDG 3 - Good Health and Well-being
title_short Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
title_full Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
title_fullStr Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
title_full_unstemmed Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
title_sort Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles
author Cardoso, Maria Margarida
author_facet Cardoso, Maria Margarida
Peça, Inês N.
Bicho, Ana
author_role author
author2 Peça, Inês N.
Bicho, Ana
author2_role author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Cardoso, Maria Margarida
Peça, Inês N.
Bicho, Ana
dc.subject.por.fl_str_mv Baker–Lonsdale model
doxorubicin
drug-controlled release
nanoparticles
PLGA
PLGA-PEG copolymers
Materials Science(all)
Condensed Matter Physics
SDG 3 - Good Health and Well-being
topic Baker–Lonsdale model
doxorubicin
drug-controlled release
nanoparticles
PLGA
PLGA-PEG copolymers
Materials Science(all)
Condensed Matter Physics
SDG 3 - Good Health and Well-being
description The authors acknowledge the support from FCT/MCTES through the projects PTDC/EQU/EPR/119631/2010. The authors wish to thank the Analytical Services Laboratory of REQUIMTE for providing the DSC results. Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-10-29T00:37:52Z
2024-07-17
2024-07-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/174214
url http://hdl.handle.net/10362/174214
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cardoso, M. M., Peça, I. N., & Bicho, A. (2024). Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles. Materials, 17(14), Article 3544. https://doi.org/10.3390/ma17143544
1996-1944
PURE: 101113409
https://doi.org/10.3390/ma17143544
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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