Nasosinusal mucormycosis – clinical reports and literature review

• Main Author: Novas, Ana Casas
• Publication Date: 2011
• Other Authors: Amaro, Carla, Ribeiro, Susana, Montemor, Rudolfo, Ribeiro, Cristóvão, Barros, Ezequiel
• Format: Article
• Language: por
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://doi.org/10.34631/sporl.164
• topic: Sinusitis; fungus; amphotericin; Sinusite; fúngica; anfotericina

Mucormycosis is a life-threatening fungal infection, commonly with fatal evolution. This fungus is a saprophytic organism which can become pathogenic in specific conditions, particularly in immunocompromised patients (diabetes mellitus, especially those with ketoacidosis; solid malignancies, haematologic malignancies, patients undergoing treatment with glucocorticosteroid). The disease process starts with inhalation of the fungus into the paranasal sinus. The fungus may spread to invade the palate, sphenoid sinus, cavernous sinus, orbits or cranially to invade the brain. The keys to successful therapy include suspicion of the diagnosis and early recognition of the signs and symptons, correction of underlying medical disorders, aggressive medical and surgical intervention.We report three cases of rhinocerebral mucormycosis in immunocompromised patients (males), mean age 70 years with histopathological diagnosis of mucormycosis, treated in the last year (2009), at the Hospital S. José. All patients were treated with amphotericin B and two of them had surgical debridement of involved tissue. Two dieds.Mucormycosis rhino-sinusal is a serious clinical that requires an exact diagnosis and a quick treatement, since it still causes high mortality both the infection characteristics and the underlying medical condition of the patients.