Deep into the proteomic network of hemozoin formation in the malaria parasite

Bibliographic Details
Main Author: Baptista, Vitória Cunha
Publication Date: 2024
Other Authors: Silva, Miguel, Freitas, Bruno, Catarino, Susana Oliveira, Vizoso-Vázquez, Angél, Veiga, Maria Isabel
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/93677
Summary: FEBS3+ Meeting: Exploring Molecular Frontiers, Pula, Croatia, 25-28 September 2024
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spelling Deep into the proteomic network of hemozoin formation in the malaria parasiteEngenharia e Tecnologia::Engenharia MédicaSaúde de qualidadeFEBS3+ Meeting: Exploring Molecular Frontiers, Pula, Croatia, 25-28 September 2024Malaria is an infectious disease caused by Plasmodium parasites transmitted to and between people by mosquitoes. Despite progress in its control, malaria still threatens half of the world’s population yearly, owing to the capacity of the parasite to develop resistance to antimalarial drugs treatment. Thus, innovative intervention measures are urgent and strictly depend on our better understanding of the parasite’s complex biology. Throughout their lifecycle, malaria parasites repeatedly invade human host erythrocytes, causing the symptoms of the disease. Within erythrocytes, parasites endocytose hemoglobin into an acidic digestive vacuole. Hemoglobin degradation causes the release of toxic free heme that the parasite sequesters into hemozoin crystals to avoid cell damage. Despite not being well resolved, with different theories proposed for hemozoin formation, this process is vital for the parasite and exploited in antimalarial chemotherapy. Recently, a lipocalin was identified in P. falciparum and its conditional knockout demonstrated hemozoin crystal malformation and consequently parasite death. Thus, being lipocalin somehow involved in hemozoin formation, we sought to study its interactors, aiming to identify the players in hemozoin formation. For this, we leverage the yeast to hybrid approach with lipocalin as a bait, in addition to mass spectrometry of gene-edited parasite lines overexpressing lipocalin. This work will improve the knowledge around hemozoin formation and possibly provide a repertoire of targets for the development of new malaria therapies.Universidade do MinhoBaptista, Vitória CunhaSilva, MiguelFreitas, BrunoCatarino, Susana OliveiraVizoso-Vázquez, AngélVeiga, Maria Isabel2024-09-282024-09-28T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/1822/93677enghttps://febs3pula.com/info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-11-23T01:18:29Zoai:repositorium.sdum.uminho.pt:1822/93677Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:15:38.401365Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Deep into the proteomic network of hemozoin formation in the malaria parasite
title Deep into the proteomic network of hemozoin formation in the malaria parasite
spellingShingle Deep into the proteomic network of hemozoin formation in the malaria parasite
Baptista, Vitória Cunha
Engenharia e Tecnologia::Engenharia Médica
Saúde de qualidade
title_short Deep into the proteomic network of hemozoin formation in the malaria parasite
title_full Deep into the proteomic network of hemozoin formation in the malaria parasite
title_fullStr Deep into the proteomic network of hemozoin formation in the malaria parasite
title_full_unstemmed Deep into the proteomic network of hemozoin formation in the malaria parasite
title_sort Deep into the proteomic network of hemozoin formation in the malaria parasite
author Baptista, Vitória Cunha
author_facet Baptista, Vitória Cunha
Silva, Miguel
Freitas, Bruno
Catarino, Susana Oliveira
Vizoso-Vázquez, Angél
Veiga, Maria Isabel
author_role author
author2 Silva, Miguel
Freitas, Bruno
Catarino, Susana Oliveira
Vizoso-Vázquez, Angél
Veiga, Maria Isabel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Baptista, Vitória Cunha
Silva, Miguel
Freitas, Bruno
Catarino, Susana Oliveira
Vizoso-Vázquez, Angél
Veiga, Maria Isabel
dc.subject.por.fl_str_mv Engenharia e Tecnologia::Engenharia Médica
Saúde de qualidade
topic Engenharia e Tecnologia::Engenharia Médica
Saúde de qualidade
description FEBS3+ Meeting: Exploring Molecular Frontiers, Pula, Croatia, 25-28 September 2024
publishDate 2024
dc.date.none.fl_str_mv 2024-09-28
2024-09-28T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/93677
url https://hdl.handle.net/1822/93677
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://febs3pula.com/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833597976818221056

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