Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia

Bibliographic Details
Main Author: de Carvalho, Álvaro
Publication Date: 2022
Other Authors: Virgolino, Ana, Queirós, Paula, Oliveira Henriques, Ana Rita, Canhão, Helena, Rodrigues, Ana Maria, Barbosa, Veneranda, Rodrigues, Joana, Germano De Sousa, José, Guimarães, Miguel
Format: Article
Language: por
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/142162
Summary: Funding Information: This research was funded by Fundação Álvaro Carvalho (funding manager), Fundação Vox Populi, Fundação Manuel Viegas Guerreiro, and the Claude and Sofia Marion Foundation. The writing of the paper was also funded by the Fundação para a Ciência e a Tecnologia under the grants UIDB/04295/2020, UIDP/04295/2020, UIDB/04293/2020, and UIDP/04923/2020.
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spelling Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da PandemiaSARS-CoV-2 Antibody Prevalence in the Portuguese Municipality of Vila Nova de Gaia after the First Wave of the PandemicAntibodies, ViralCOVID-19Epidemiological MonitoringPortugalSARS-CoV-2Seroepidemiologic StudiesMedicine(all)Funding Information: This research was funded by Fundação Álvaro Carvalho (funding manager), Fundação Vox Populi, Fundação Manuel Viegas Guerreiro, and the Claude and Sofia Marion Foundation. The writing of the paper was also funded by the Fundação para a Ciência e a Tecnologia under the grants UIDB/04295/2020, UIDP/04295/2020, UIDB/04293/2020, and UIDP/04923/2020.Introduction: Assessment of SARS-CoV-2 seroprevalence may detect the real spread of the virus because antibody data can provide a long-lasting measure of infection. Existing serological studies in Portugal have tested new serology methods, albeit with small sample sizes and a lack the focus on geographical regions with a high rate of infection cases. The aim of this study was to estimate the serological prevalence of SARS-CoV-2 in Vila Nova de Gaia, the most populous municipality in the north of Portugal and one of those most affected during the first pandemic wave. Material and Methods: A cross-sectional observational study was conducted between June 23rd and July 17th, 2020. Included in the cohort were 18- to 74-year-old men and women living in the municipality of Vila Nova de Gaia, who were sampled through a non-probabilistic quota-based approach. Cases with a previous RT-PCR diagnosis of COVID-19 were excluded. Sociodemographic and clinical information was collected using a self-administered, written questionnaire. Blood samples were collected for serological laboratory analysis to detect and quantify SARS-CoV-2 anti-IgG antibodies. Results: We tested 2754 participants. Our results show a SARS-CoV-2 seroprevalence of 3.03% (95% confidence interval: 2.37% – 3.87%). Being a smoker (odds ratio: 0.382, 95% confidence interval: 0.147 – 0.99) and having symptoms of COVID-19 (odds ratio: 2.480, 95% confidence interval: 1.360 – 4.522) were consistently associated with lower and higher odds of SARS-CoV-2 antibody presence, respectively, regardless of the analytic design. Moreover, without adjusting for any variables, having had contact with an infected person within the household was associated with increased odds of a positive test (odds ratio: 9.684, 95% confidence interval: 4.06 – 23.101); after adjusting, having self-reported chronic diseases (odds ratio: 0.448, 95% confidence interval: 0.213 – 0.941) was associated with decreased odds. Conclusion: This was the first study to estimate the serological prevalence of SARS-CoV-2 in one of the most populous municipalities in Portugal, representing the first step in the development of an epidemiological surveillance system in Portugal, which can help to improve the diagnosis of COVID-19.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)RUNde Carvalho, ÁlvaroVirgolino, AnaQueirós, PaulaOliveira Henriques, Ana RitaCanhão, HelenaRodrigues, Ana MariaBarbosa, VenerandaRodrigues, JoanaGermano De Sousa, JoséGuimarães, Miguel2022-07-19T22:29:33Z2022-062022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/142162por0870-399XPURE: 45347079https://doi.org/10.20344/amp.17676info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-09-23T01:38:16Zoai:run.unl.pt:10362/142162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:34:22.273873Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
SARS-CoV-2 Antibody Prevalence in the Portuguese Municipality of Vila Nova de Gaia after the First Wave of the Pandemic
title Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
spellingShingle Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
de Carvalho, Álvaro
Antibodies, Viral
COVID-19
Epidemiological Monitoring
Portugal
SARS-CoV-2
Seroepidemiologic Studies
Medicine(all)
title_short Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
title_full Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
title_fullStr Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
title_full_unstemmed Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
title_sort Prevalência de Anticorpos Contra SARS-CoV-2 na População Residente no Município Português de Vila Nova de Gaia após a Primeira Onda da Pandemia
author de Carvalho, Álvaro
author_facet de Carvalho, Álvaro
Virgolino, Ana
Queirós, Paula
Oliveira Henriques, Ana Rita
Canhão, Helena
Rodrigues, Ana Maria
Barbosa, Veneranda
Rodrigues, Joana
Germano De Sousa, José
Guimarães, Miguel
author_role author
author2 Virgolino, Ana
Queirós, Paula
Oliveira Henriques, Ana Rita
Canhão, Helena
Rodrigues, Ana Maria
Barbosa, Veneranda
Rodrigues, Joana
Germano De Sousa, José
Guimarães, Miguel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv de Carvalho, Álvaro
Virgolino, Ana
Queirós, Paula
Oliveira Henriques, Ana Rita
Canhão, Helena
Rodrigues, Ana Maria
Barbosa, Veneranda
Rodrigues, Joana
Germano De Sousa, José
Guimarães, Miguel
dc.subject.por.fl_str_mv Antibodies, Viral
COVID-19
Epidemiological Monitoring
Portugal
SARS-CoV-2
Seroepidemiologic Studies
Medicine(all)
topic Antibodies, Viral
COVID-19
Epidemiological Monitoring
Portugal
SARS-CoV-2
Seroepidemiologic Studies
Medicine(all)
description Funding Information: This research was funded by Fundação Álvaro Carvalho (funding manager), Fundação Vox Populi, Fundação Manuel Viegas Guerreiro, and the Claude and Sofia Marion Foundation. The writing of the paper was also funded by the Fundação para a Ciência e a Tecnologia under the grants UIDB/04295/2020, UIDP/04295/2020, UIDB/04293/2020, and UIDP/04923/2020.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-19T22:29:33Z
2022-06
2022-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/142162
url http://hdl.handle.net/10362/142162
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 0870-399X
PURE: 45347079
https://doi.org/10.20344/amp.17676
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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