Dendritic Cells: A Spot on Sialic Acid

Bibliographic Details
Main Author: Crespo, Hélio
Publication Date: 2013
Other Authors: Lau,  Joseph T Y, Videira, Paula A
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/23559
Summary: This work was supported by the Portuguese Foundation for Science and Technology (FCT) - PTDC/SAU-MII/67561/2006 and CEDOC (Paula A. Videira) and SFRH/BD/61204/2009 (He lio J. Crespo). FCT is co-financed by European Social Fund (ESF) under Human Potential Operation Program (POPH) from National Strategic Reference Framework (NSRF).
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spelling Dendritic Cells: A Spot on Sialic Acidsialylationsialic acidhost-pathogen interactionlectinsdendritic celldendritic cellsialic acidsialylationlectinshost-pathogen interactionThis work was supported by the Portuguese Foundation for Science and Technology (FCT) - PTDC/SAU-MII/67561/2006 and CEDOC (Paula A. Videira) and SFRH/BD/61204/2009 (He lio J. Crespo). FCT is co-financed by European Social Fund (ESF) under Human Potential Operation Program (POPH) from National Strategic Reference Framework (NSRF).Glycans decorating cell surface and secreted proteins and lipids occupy the juncture where critical host-host and host-pathogen interactions occur. The role of glycan epitopes in cell-cell and cell-pathogen adhesive events is already well-established, and cell surface glycan structures change rapidly in response to stimulus and inflammatory cues. Despite the wide acceptance that glycans are centrally implicated in immunity, exactly how glycans and their changes contribute to the overall immune response remains poorly defined. Sialic acids are unique sugars that usually occupy the terminal position of the glycan chains and may be modified by external factors, such as pathogens, or upon specific physiological cellular events. At cell surface, sialic acid-modified structures form the key fundamental determinants for a number of receptors with known involvement in cellular adhesiveness and cell trafficking, such as the Selectins and the Siglec families of carbohydrate recognizing receptors. Dendritic cells (DCs) preside over the transition from innate to the adaptive immune repertoires, and no other cell has such relevant role in antigen screening, uptake, and its presentation to lymphocytes, ultimately triggering the adaptive immune response. Interestingly, sialic acid-modified structures are involved in all DC functions, such as antigen uptake, DC migration, and capacity to prime T cell responses. Sialic acid content changes along DC differentiation and activation and, while, not yet fully understood, these changes have important implications in DC functions. This review focuses on the developmental regulation of DC surface sialic acids and how manipulation of DC surface sialic acids can affect immune-critical DC functions by altering antigen endocytosis, pathogen and tumor cell recognition, cell recruitment, and capacity for T cell priming. The existing evidence points to a potential of DC surface sialylation as a therapeutic target to improve and diversify DC-based therapies.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNCrespo, HélioLau,  Joseph T YVideira, Paula A2017-09-25T22:00:40Z2013-12-272013-12-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/23559eng1664-3224PURE: 204301https://doi.org/10.3389/fimmu.2013.00491info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:27:56Zoai:run.unl.pt:10362/23559Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:59:06.550544Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Dendritic Cells: A Spot on Sialic Acid
title Dendritic Cells: A Spot on Sialic Acid
spellingShingle Dendritic Cells: A Spot on Sialic Acid
Crespo, Hélio
sialylation
sialic acid
host-pathogen interaction
lectins
dendritic cell
dendritic cell
sialic acid
sialylation
lectins
host-pathogen interaction
title_short Dendritic Cells: A Spot on Sialic Acid
title_full Dendritic Cells: A Spot on Sialic Acid
title_fullStr Dendritic Cells: A Spot on Sialic Acid
title_full_unstemmed Dendritic Cells: A Spot on Sialic Acid
title_sort Dendritic Cells: A Spot on Sialic Acid
author Crespo, Hélio
author_facet Crespo, Hélio
Lau,  Joseph T Y
Videira, Paula A
author_role author
author2 Lau,  Joseph T Y
Videira, Paula A
author2_role author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Crespo, Hélio
Lau,  Joseph T Y
Videira, Paula A
dc.subject.por.fl_str_mv sialylation
sialic acid
host-pathogen interaction
lectins
dendritic cell
dendritic cell
sialic acid
sialylation
lectins
host-pathogen interaction
topic sialylation
sialic acid
host-pathogen interaction
lectins
dendritic cell
dendritic cell
sialic acid
sialylation
lectins
host-pathogen interaction
description This work was supported by the Portuguese Foundation for Science and Technology (FCT) - PTDC/SAU-MII/67561/2006 and CEDOC (Paula A. Videira) and SFRH/BD/61204/2009 (He lio J. Crespo). FCT is co-financed by European Social Fund (ESF) under Human Potential Operation Program (POPH) from National Strategic Reference Framework (NSRF).
publishDate 2013
dc.date.none.fl_str_mv 2013-12-27
2013-12-27T00:00:00Z
2017-09-25T22:00:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/23559
url http://hdl.handle.net/10362/23559
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-3224
PURE: 204301
https://doi.org/10.3389/fimmu.2013.00491
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596342218260480

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