Diagnosis of monoclonal gammopathy of renal significance

Detalhes bibliográficos
Autor(a) principal: Correia,Sofia O
Data de Publicação: 2018
Outros Autores: Santos,Sofia, Martins,La Salete, Santos,Josefina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100008
Resumo: Monoclonal gammopathies are a heterogeneous group of disorders characterized by clonal proliferation of immunoglobulin produced by B-lymphocytes or plasma cell clone. The term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. Screening for monoclonal immunoglobulin and an appropriate hematologic workup are fundamental and sometimes a difficult challenge, with therapeutic and prognostic implications. Kidney biopsy is essential to determine the exact nature of the lesion and to evaluate the severity of renal disease. In this review we discuss the clinical and pathologic features of MGRS, highlighting the most diagnostic difficulties and current therapeutic options
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spelling Diagnosis of monoclonal gammopathy of renal significanceMonoclonal gammopathy of renal significanceM proteinrenal pathologytreatmentMonoclonal gammopathies are a heterogeneous group of disorders characterized by clonal proliferation of immunoglobulin produced by B-lymphocytes or plasma cell clone. The term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. Screening for monoclonal immunoglobulin and an appropriate hematologic workup are fundamental and sometimes a difficult challenge, with therapeutic and prognostic implications. Kidney biopsy is essential to determine the exact nature of the lesion and to evaluate the severity of renal disease. In this review we discuss the clinical and pathologic features of MGRS, highlighting the most diagnostic difficulties and current therapeutic optionsSociedade Portuguesa de Nefrologia2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100008Portuguese Journal of Nephrology & Hypertension v.32 n.1 2018reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100008Correia,Sofia OSantos,SofiaMartins,La SaleteSantos,Josefinainfo:eu-repo/semantics/openAccess2024-02-06T17:04:57Zoai:scielo:S0872-01692018000100008Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T12:54:31.613828Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Diagnosis of monoclonal gammopathy of renal significance
title Diagnosis of monoclonal gammopathy of renal significance
spellingShingle Diagnosis of monoclonal gammopathy of renal significance
Correia,Sofia O
Monoclonal gammopathy of renal significance
M protein
renal pathology
treatment
title_short Diagnosis of monoclonal gammopathy of renal significance
title_full Diagnosis of monoclonal gammopathy of renal significance
title_fullStr Diagnosis of monoclonal gammopathy of renal significance
title_full_unstemmed Diagnosis of monoclonal gammopathy of renal significance
title_sort Diagnosis of monoclonal gammopathy of renal significance
author Correia,Sofia O
author_facet Correia,Sofia O
Santos,Sofia
Martins,La Salete
Santos,Josefina
author_role author
author2 Santos,Sofia
Martins,La Salete
Santos,Josefina
author2_role author
author
author
dc.contributor.author.fl_str_mv Correia,Sofia O
Santos,Sofia
Martins,La Salete
Santos,Josefina
dc.subject.por.fl_str_mv Monoclonal gammopathy of renal significance
M protein
renal pathology
treatment
topic Monoclonal gammopathy of renal significance
M protein
renal pathology
treatment
description Monoclonal gammopathies are a heterogeneous group of disorders characterized by clonal proliferation of immunoglobulin produced by B-lymphocytes or plasma cell clone. The term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. Screening for monoclonal immunoglobulin and an appropriate hematologic workup are fundamental and sometimes a difficult challenge, with therapeutic and prognostic implications. Kidney biopsy is essential to determine the exact nature of the lesion and to evaluate the severity of renal disease. In this review we discuss the clinical and pathologic features of MGRS, highlighting the most diagnostic difficulties and current therapeutic options
publishDate 2018
dc.date.none.fl_str_mv 2018-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100008
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.32 n.1 2018
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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