Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation

Bibliographic Details
Main Author: Madeira, Natália
Publication Date: 2020
Other Authors: Drumond, Ana, Fonseca, Rosalina
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/170163
Summary: © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activationamygdalacannabinoid receptorlong-term potentiationsynaptic competitionsynaptic cooperation© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.The acquisition of fear memories involves plasticity of the thalamic and cortical pathways to the lateral amygdala (LA). In turn, the maintenance of synaptic plasticity requires the interplay between input-specific synaptic tags and the allocation of plasticity-related proteins. Based on this interplay, weakly activated synapses can express long-lasting forms of synaptic plasticity by cooperating with strongly activated synapses. Increasing the number of activated synapses can shift cooperation to competition. Synaptic cooperation and competition can determine whether two events, separated in time, are associated or whether a particular event is selected for storage. The rules that determine whether synapses cooperate or compete are unknown. We found that synaptic cooperation and competition, in the LA, are determined by the temporal sequence of cortical and thalamic stimulation and that the strength of the synaptic tag is modulated by the endocannabinoid signaling. This modulation is particularly effective in thalamic synapses, supporting a critical role of endocannabinoids in restricting thalamic plasticity. Also, we found that the availability of synaptic proteins is activity-dependent, shifting competition to cooperation. Our data present the first evidence that presynaptic modulation of synaptic activation, by the cannabinoid signaling, functions as a temporal gating mechanism limiting synaptic cooperation and competition.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMadeira, NatáliaDrumond, AnaFonseca, Rosalina2024-07-30T22:10:15Z2020-072020-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/170163eng1047-3211PURE: 17765402https://doi.org/10.1093/cercor/bhaa026info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-09-09T01:39:13Zoai:run.unl.pt:10362/170163Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T18:47:01.351327Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
title Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
spellingShingle Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
Madeira, Natália
amygdala
cannabinoid receptor
long-term potentiation
synaptic competition
synaptic cooperation
title_short Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
title_full Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
title_fullStr Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
title_full_unstemmed Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
title_sort Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
author Madeira, Natália
author_facet Madeira, Natália
Drumond, Ana
Fonseca, Rosalina
author_role author
author2 Drumond, Ana
Fonseca, Rosalina
author2_role author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Madeira, Natália
Drumond, Ana
Fonseca, Rosalina
dc.subject.por.fl_str_mv amygdala
cannabinoid receptor
long-term potentiation
synaptic competition
synaptic cooperation
topic amygdala
cannabinoid receptor
long-term potentiation
synaptic competition
synaptic cooperation
description © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
2020-07-01T00:00:00Z
2024-07-30T22:10:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/170163
url http://hdl.handle.net/10362/170163
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1047-3211
PURE: 17765402
https://doi.org/10.1093/cercor/bhaa026
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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