Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine

Bibliographic Details
Main Author: Teixeira, Dulce
Publication Date: 2018
Other Authors: Prudêncio, Cristina, Azenha, Manuel, Vieira, Mónica
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.22/25684
Summary: Neurodegenerative diseases affect around 30 million people worldwide, thus new methods that can facilitate research of such diseases are essential. Neurotransmitters, characterised as critical regulators of several neurological disorders, have been the target for the development of such methods. Besides, oxidative/ nitrosative stress has been associated with several neurodegenerative diseases and is thought to play an important role in their pathogenesis. Therefore, the development of bioanalytical methods for quantification of neurotransmitters and oxidative stress-associated molecules seems to be an interesting approach. The aim of this study was to develop a simple, rapid, low-cost and sensitive octopamine (OCT) and 3-nitrotyrosine (3-NT) quantification method for use in biological models.
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spelling Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosineOctapamine3-NitrotyrosineHPLCNeurodegenerative diseasesNeurodegenerative diseases affect around 30 million people worldwide, thus new methods that can facilitate research of such diseases are essential. Neurotransmitters, characterised as critical regulators of several neurological disorders, have been the target for the development of such methods. Besides, oxidative/ nitrosative stress has been associated with several neurodegenerative diseases and is thought to play an important role in their pathogenesis. Therefore, the development of bioanalytical methods for quantification of neurotransmitters and oxidative stress-associated molecules seems to be an interesting approach. The aim of this study was to develop a simple, rapid, low-cost and sensitive octopamine (OCT) and 3-nitrotyrosine (3-NT) quantification method for use in biological models.Escola Superior de Saúde P.PortoREPOSITÓRIO P.PORTOTeixeira, DulcePrudêncio, CristinaAzenha, ManuelVieira, Mónica2024-06-17T14:45:28Z2018-05-182018-05-18T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10400.22/25684eng978-989-20-8533-3info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-07T09:58:59Zoai:recipp.ipp.pt:10400.22/25684Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:24:17.211546Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
title Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
spellingShingle Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
Teixeira, Dulce
Octapamine
3-Nitrotyrosine
HPLC
Neurodegenerative diseases
title_short Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
title_full Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
title_fullStr Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
title_full_unstemmed Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
title_sort Development of a new method for the detection and quantification of octopamine and 3-nitrotyrosine
author Teixeira, Dulce
author_facet Teixeira, Dulce
Prudêncio, Cristina
Azenha, Manuel
Vieira, Mónica
author_role author
author2 Prudêncio, Cristina
Azenha, Manuel
Vieira, Mónica
author2_role author
author
author
dc.contributor.none.fl_str_mv REPOSITÓRIO P.PORTO
dc.contributor.author.fl_str_mv Teixeira, Dulce
Prudêncio, Cristina
Azenha, Manuel
Vieira, Mónica
dc.subject.por.fl_str_mv Octapamine
3-Nitrotyrosine
HPLC
Neurodegenerative diseases
topic Octapamine
3-Nitrotyrosine
HPLC
Neurodegenerative diseases
description Neurodegenerative diseases affect around 30 million people worldwide, thus new methods that can facilitate research of such diseases are essential. Neurotransmitters, characterised as critical regulators of several neurological disorders, have been the target for the development of such methods. Besides, oxidative/ nitrosative stress has been associated with several neurodegenerative diseases and is thought to play an important role in their pathogenesis. Therefore, the development of bioanalytical methods for quantification of neurotransmitters and oxidative stress-associated molecules seems to be an interesting approach. The aim of this study was to develop a simple, rapid, low-cost and sensitive octopamine (OCT) and 3-nitrotyrosine (3-NT) quantification method for use in biological models.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-18
2018-05-18T00:00:00Z
2024-06-17T14:45:28Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/25684
url http://hdl.handle.net/10400.22/25684
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 978-989-20-8533-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Escola Superior de Saúde P.Porto
publisher.none.fl_str_mv Escola Superior de Saúde P.Porto
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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