Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay

Bibliographic Details
Main Author: Serafim, Rodrigo B.
Publication Date: 2022
Other Authors: Dal-Pizzol, Felipe, Souza-Dantas, Vicente, Soares, Marcio, Bozza, Fernando A., Povoa, Pedro, Luiz, Ronir Raggio, Lapa e Silva, José R., Salluh, Jorge I.F.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/146145
Summary: Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2022 by the authors.
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spelling Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Staycognitive dysfunctioncritically illdeliriumICUsubsyndromal deliriumMedicine(all)Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2022 by the authors.Despite recent advances in the field, the association between subsyndromal delirium (SSD) in the ICU and poor outcomes is not entirely clear. We performed a retrospective multicentric observational study analyzing mental status during the first 72 h of ICU stay. Of the 681 patients included, SSD occurred in 22.7%. Considering the worst cognitive assessment during the first 72 h, 233 (34%) patients had normal mental status, 124 (18%) patients had SSD and 324 (48%) patients had delirium or coma. SSD was not independently associated with an increased risk of death when compared with normal mental status (OR 95%IC 1.0 vs. 1.35 [0.73–1.49], p = 0.340), but was associated with a longer ICU LOS (7.0 (4–12) vs. 4 (3–8) days, p < 0.001). SSD patients who deteriorated to delirium or coma (21%) had a longer ICU LOS in comparison with those who improved or maintained mental status (8 (5–11) vs. 6 (4–8) days, p = 0.025), but did not have an increase in mortality. The main factors associated with the progression from SSD to delirium or coma were the use of mechanical ventilation, the use of intravenous benzodiazepines and a baseline APACHE II score > 23 points. Our findings support the association of SSD with increased ICU LOS, but not with ICU mortality. Monitoring the trajectory of SSD early at ICU admission can help to identify patients with increased risk of conversion from SSD to delirium or coma.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSerafim, Rodrigo B.Dal-Pizzol, FelipeSouza-Dantas, VicenteSoares, MarcioBozza, Fernando A.Povoa, PedroLuiz, Ronir RaggioLapa e Silva, José R.Salluh, Jorge I.F.2022-12-12T22:14:31Z2022-112022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/146145eng2077-0383PURE: 48188375https://doi.org/10.3390/jcm11226797info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:07:17Zoai:run.unl.pt:10362/146145Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:01.042769Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
title Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
spellingShingle Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
Serafim, Rodrigo B.
cognitive dysfunction
critically ill
delirium
ICU
subsyndromal delirium
Medicine(all)
title_short Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
title_full Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
title_fullStr Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
title_full_unstemmed Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
title_sort Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay
author Serafim, Rodrigo B.
author_facet Serafim, Rodrigo B.
Dal-Pizzol, Felipe
Souza-Dantas, Vicente
Soares, Marcio
Bozza, Fernando A.
Povoa, Pedro
Luiz, Ronir Raggio
Lapa e Silva, José R.
Salluh, Jorge I.F.
author_role author
author2 Dal-Pizzol, Felipe
Souza-Dantas, Vicente
Soares, Marcio
Bozza, Fernando A.
Povoa, Pedro
Luiz, Ronir Raggio
Lapa e Silva, José R.
Salluh, Jorge I.F.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Serafim, Rodrigo B.
Dal-Pizzol, Felipe
Souza-Dantas, Vicente
Soares, Marcio
Bozza, Fernando A.
Povoa, Pedro
Luiz, Ronir Raggio
Lapa e Silva, José R.
Salluh, Jorge I.F.
dc.subject.por.fl_str_mv cognitive dysfunction
critically ill
delirium
ICU
subsyndromal delirium
Medicine(all)
topic cognitive dysfunction
critically ill
delirium
ICU
subsyndromal delirium
Medicine(all)
description Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2022 by the authors.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-12T22:14:31Z
2022-11
2022-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/146145
url http://hdl.handle.net/10362/146145
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2077-0383
PURE: 48188375
https://doi.org/10.3390/jcm11226797
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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