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New frontiers for anti-biofilm drug development

Bibliographic Details
Main Author: Ribeiro, Suzana M.
Publication Date: 2016
Other Authors: Felício, Mário Romão, Boas, Esther Vilas, Abreu, Sónia Gonçalves, Costa, Fabrício F., Samy, Ramar Perumal, Santos, Nuno, Franco, Octávio L.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/37673
Summary: © 2016 Elsevier Inc. All rights reserved
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spelling New frontiers for anti-biofilm drug developmentAnti-biofilm peptidesBiofilmsDrug repurposingNanotechnologyPolymicrobial biofilm© 2016 Elsevier Inc. All rights reservedPathogenic microbial biofilm, a consortium of microbial cells protected by a self-produced polymer matrix, is considered a worldwide challenge due to the inherent antibiotic resistance conferred by its lifestyle. Living, as it does, in a community of microbial organisms in a clinical situation, makes it responsible for severe and dangerous cases of infection. Combating this organisation of cells usually requires high antibiotic doses for a prolonged time, and these approaches often fail, contributing to infection persistence. In addition to therapeutic limitations, biofilms can be a source of infections when they grow inmedical devices. The challenge imposed by biofilms has mobilised researchers in the entire world to prospect or develop alternatives to control biofilms. In this context, this review summarises the new frontiers that could be used in clinical circumstances in order to prevent or eliminate pathogenic biofilms.This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil), Conselho Nacional de Pesquisa e Desenvolvimento (CNPq, Brazil), Fundação de Amparo à Pesquisa do Distrito Federal (FAPDF, Brazil), Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT, Brazil), Fundação para a Ciência e a Tecnologia –Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal), including the fellowcship SPRH/BD/ 100517/2014 to M.R.F., and Marie Skłodowska-Curie Research and Innovation Staff Exchange (MSCA-RISE, European Union) project INPACT (call H2020-MSCA-RISE-2014, grant agreement 644167).ElsevierRepositório da Universidade de LisboaRibeiro, Suzana M.Felício, Mário RomãoBoas, Esther VilasAbreu, Sónia GonçalvesCosta, Fabrício F.Samy, Ramar PerumalSantos, NunoFranco, Octávio L.2019-03-25T11:38:39Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10451/37673engPharmacology & Therapeutics 160 (2016) 133–1440163-725810.1016/j.pharmthera.2016.02.006info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:05:32Zoai:repositorio.ulisboa.pt:10451/37673Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:02:24.830112Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv New frontiers for anti-biofilm drug development
title New frontiers for anti-biofilm drug development
spellingShingle New frontiers for anti-biofilm drug development
Ribeiro, Suzana M.
Anti-biofilm peptides
Biofilms
Drug repurposing
Nanotechnology
Polymicrobial biofilm
title_short New frontiers for anti-biofilm drug development
title_full New frontiers for anti-biofilm drug development
title_fullStr New frontiers for anti-biofilm drug development
title_full_unstemmed New frontiers for anti-biofilm drug development
title_sort New frontiers for anti-biofilm drug development
author Ribeiro, Suzana M.
author_facet Ribeiro, Suzana M.
Felício, Mário Romão
Boas, Esther Vilas
Abreu, Sónia Gonçalves
Costa, Fabrício F.
Samy, Ramar Perumal
Santos, Nuno
Franco, Octávio L.
author_role author
author2 Felício, Mário Romão
Boas, Esther Vilas
Abreu, Sónia Gonçalves
Costa, Fabrício F.
Samy, Ramar Perumal
Santos, Nuno
Franco, Octávio L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ribeiro, Suzana M.
Felício, Mário Romão
Boas, Esther Vilas
Abreu, Sónia Gonçalves
Costa, Fabrício F.
Samy, Ramar Perumal
Santos, Nuno
Franco, Octávio L.
dc.subject.por.fl_str_mv Anti-biofilm peptides
Biofilms
Drug repurposing
Nanotechnology
Polymicrobial biofilm
topic Anti-biofilm peptides
Biofilms
Drug repurposing
Nanotechnology
Polymicrobial biofilm
description © 2016 Elsevier Inc. All rights reserved
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2019-03-25T11:38:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/37673
url http://hdl.handle.net/10451/37673
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmacology & Therapeutics 160 (2016) 133–144
0163-7258
10.1016/j.pharmthera.2016.02.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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