Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin

• Main Author: Mascarenhas-Melo, Filipa
• Publication Date: 2013
• Other Authors: Sereno, José, Teixeira-Lemos, Edite, Marado, Daniela, Palavra, Filipe, Pinto, Rui, Rocha-Pereira, Petronila, Teixeira, Frederico, Reis, Flávio
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://hdl.handle.net/10316/109752; https://doi.org/10.1155/2013/612038
• topic: Adiponectin; Adult; Aged; Aryldialkylphosphatase; Biomarkers; Blood Glucose; Blood Pressure; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cholesterol, HDL; Female; Humans; Inflammation; Intercellular Adhesion Molecule-1; Lipid Metabolism; Lipoproteins, LDL; Male; Middle Aged; Oxygen; Risk Factors; Tumor Necrosis Factor-alpha; Uric Acid; Vascular Endothelial Growth Factor A; Waist Circumference; Gene Expression Regulation

To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.