Exploiting Codon-Triplets Association for Genome Primary Structure Analysis

Bibliographic Details
Main Author: Lousado, José
Publication Date: 2008
Other Authors: Oliveira, José, Moura, Gabriela, Santos, Manuel
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.19/1065
Summary: Abstract— The way evolution shapes the arrangement of synonymous codons within open reading frames (ORF) for fine tuning mRNA decoding efficiency is not yet understood. Since the ribosome has 3 tRNA binding sites, the context of triplets should be relevant to decoding fidelity and efficiency. We have developed a software application for large-scale analysis of codon-triplet associations to shed new light into this problem. The developed algorithms identify codon-triplets context biases, allowing for large scale comparative codon-triplet analysis and for identification of alterations to the standard genetic code.
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spelling Exploiting Codon-Triplets Association for Genome Primary Structure AnalysisBioinformaticscomparative genomicsdata miningAbstract— The way evolution shapes the arrangement of synonymous codons within open reading frames (ORF) for fine tuning mRNA decoding efficiency is not yet understood. Since the ribosome has 3 tRNA binding sites, the context of triplets should be relevant to decoding fidelity and efficiency. We have developed a software application for large-scale analysis of codon-triplet associations to shed new light into this problem. The developed algorithms identify codon-triplets context biases, allowing for large scale comparative codon-triplet analysis and for identification of alterations to the standard genetic code.IEEE Computer SocietyInstituto Politécnico de ViseuLousado, JoséOliveira, JoséMoura, GabrielaSantos, Manuel2012-04-10T15:51:07Z20082008-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10400.19/1065eng978-0-7695-3191-5info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-06T13:59:33Zoai:repositorio.ipv.pt:10400.19/1065Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:11:54.610204Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
title Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
spellingShingle Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
Lousado, José
Bioinformatics
comparative genomics
data mining
title_short Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
title_full Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
title_fullStr Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
title_full_unstemmed Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
title_sort Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
author Lousado, José
author_facet Lousado, José
Oliveira, José
Moura, Gabriela
Santos, Manuel
author_role author
author2 Oliveira, José
Moura, Gabriela
Santos, Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto Politécnico de Viseu
dc.contributor.author.fl_str_mv Lousado, José
Oliveira, José
Moura, Gabriela
Santos, Manuel
dc.subject.por.fl_str_mv Bioinformatics
comparative genomics
data mining
topic Bioinformatics
comparative genomics
data mining
description Abstract— The way evolution shapes the arrangement of synonymous codons within open reading frames (ORF) for fine tuning mRNA decoding efficiency is not yet understood. Since the ribosome has 3 tRNA binding sites, the context of triplets should be relevant to decoding fidelity and efficiency. We have developed a software application for large-scale analysis of codon-triplet associations to shed new light into this problem. The developed algorithms identify codon-triplets context biases, allowing for large scale comparative codon-triplet analysis and for identification of alterations to the standard genetic code.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
2012-04-10T15:51:07Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.19/1065
url http://hdl.handle.net/10400.19/1065
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 978-0-7695-3191-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IEEE Computer Society
publisher.none.fl_str_mv IEEE Computer Society
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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