The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

Detalhes bibliográficos
Autor(a) principal: Crouch, LI
Data de Publicação: 2024
Outros Autores: Rodrigues, CS, Bakshani, CR, Tavares-Gomes, L, Gaifem, J, Pinho, SS
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/10216/161999
Resumo: The human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the perturbation of this symbiotic host-microbiome relationship contributes to the onset of major diseases such as chronic inflammatory diseases including Inflammatory Bowel Disease. The host glycocalyx (repertoire of glycans/sugar-chains at the surface of gut mucosa) constitutes a major biological and physical interface between the intestinal mucosa and microorganisms, as well as with the host immune system. Glycans are an essential niche for microbiota colonization and thus an important modulator of host-microorganism interactions both in homeostasis and in disease. In this review, we discuss the role of gut mucosa glycome as an instrumental pathway that regulates host-microbiome interactions in homeostasis but also in health to inflammation transition. We also discuss the power of mucosa glycosylation remodelling as an attractive preventive and therapeutic strategy to preserve gut homeostasis.
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spelling The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune systemGlycansHostHuman gut microbeImmune sensingThe human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the perturbation of this symbiotic host-microbiome relationship contributes to the onset of major diseases such as chronic inflammatory diseases including Inflammatory Bowel Disease. The host glycocalyx (repertoire of glycans/sugar-chains at the surface of gut mucosa) constitutes a major biological and physical interface between the intestinal mucosa and microorganisms, as well as with the host immune system. Glycans are an essential niche for microbiota colonization and thus an important modulator of host-microorganism interactions both in homeostasis and in disease. In this review, we discuss the role of gut mucosa glycome as an instrumental pathway that regulates host-microbiome interactions in homeostasis but also in health to inflammation transition. We also discuss the power of mucosa glycosylation remodelling as an attractive preventive and therapeutic strategy to preserve gut homeostasis.Elsevier20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/161999eng1044-532310.1016/j.smim.2024.101891Crouch, LIRodrigues, CSBakshani, CRTavares-Gomes, LGaifem, JPinho, SSinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T19:56:44Zoai:repositorio-aberto.up.pt:10216/161999Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T23:40:14.488227Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
title The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
spellingShingle The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
Crouch, LI
Glycans
Host
Human gut microbe
Immune sensing
title_short The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
title_full The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
title_fullStr The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
title_full_unstemmed The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
title_sort The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
author Crouch, LI
author_facet Crouch, LI
Rodrigues, CS
Bakshani, CR
Tavares-Gomes, L
Gaifem, J
Pinho, SS
author_role author
author2 Rodrigues, CS
Bakshani, CR
Tavares-Gomes, L
Gaifem, J
Pinho, SS
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Crouch, LI
Rodrigues, CS
Bakshani, CR
Tavares-Gomes, L
Gaifem, J
Pinho, SS
dc.subject.por.fl_str_mv Glycans
Host
Human gut microbe
Immune sensing
topic Glycans
Host
Human gut microbe
Immune sensing
description The human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the perturbation of this symbiotic host-microbiome relationship contributes to the onset of major diseases such as chronic inflammatory diseases including Inflammatory Bowel Disease. The host glycocalyx (repertoire of glycans/sugar-chains at the surface of gut mucosa) constitutes a major biological and physical interface between the intestinal mucosa and microorganisms, as well as with the host immune system. Glycans are an essential niche for microbiota colonization and thus an important modulator of host-microorganism interactions both in homeostasis and in disease. In this review, we discuss the role of gut mucosa glycome as an instrumental pathway that regulates host-microbiome interactions in homeostasis but also in health to inflammation transition. We also discuss the power of mucosa glycosylation remodelling as an attractive preventive and therapeutic strategy to preserve gut homeostasis.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/161999
url https://hdl.handle.net/10216/161999
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1044-5323
10.1016/j.smim.2024.101891
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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