Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review

Bibliographic Details
Main Author: Caldeira, Daniel
Publication Date: 2015
Other Authors: Cruz, Inês, Calé, Rita, Martins, Cristina, Pereira, Hélder, Ferreira, Joaquim J, Pinto, Fausto J., Costa, João
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/34378
Summary: © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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spelling Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic reviewHeart failureSinus rhythmPlatelet aggregation inhibitorsAnticoagulants© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.AIM: To assess the efficacy and safety of antithrombotic drugs (antiplatelet or anticoagulant drugs) compared to no antithrombotic treatment or placebo in patients with heart failure (HF) and sinus rhythm. METHODS: We searched Medline and Cochrane Library for randomized controlled trials evaluating antithrombotic treatment and no antithrombotic treatment in patients with HF and sinus rhythm. Risk ratio (RR) and 95%CIs were estimated performing meta-analysis with random effects method. RESULTS: Two studies met the inclusion criteria: Heart failure Long-term Antithrombotic Study and Warfarin/Aspirin Study in Heart failure, with 336 patients and mean follow-up 1.8-2.25 years. Stroke risk was not reduced by acetylsalicylic acid (RR = 1.18, 95%CI: 0.17-8.15), oral anticoagulation (RR = 0.30, 95%CI: 0.03-2.65) or overall antithrombotic drugs (RR = 0.52, 95%CI: 0.10-2.74). Acetylsalicylic acid showed a significant increased risk of worsening HF (RR = 1.78, 95%CI: 1.08-2.92), while oral anticoagulation had no impact in this outcome (RR = 1.03, 95%CI: 0.61-1.75). Overall antithrombotic drugs showed a significant risk increase of major bleeding (RR = 6.99, 95%CI: 0.89-54.64). CONCLUSION: Best available evidence does not support the routine use of antithrombotic drugs in patients with HF and sinus rhythm. These drugs, particularly oral anticoagulation has the hazard of increase significantly major bleeding risk.Baishideng Publishing GroupRepositório da Universidade de LisboaCaldeira, DanielCruz, InêsCalé, RitaMartins, CristinaPereira, HélderFerreira, Joaquim JPinto, Fausto J.Costa, João2018-07-27T14:24:23Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/34378engWorld J Meta-Anal 2015 February 26; 3(1): 36-422308-384010.13105/wjma.v3.i1.36info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:56:30Zoai:repositorio.ulisboa.pt:10451/34378Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:58:44.189356Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
title Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
spellingShingle Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
Caldeira, Daniel
Heart failure
Sinus rhythm
Platelet aggregation inhibitors
Anticoagulants
title_short Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
title_full Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
title_fullStr Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
title_full_unstemmed Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
title_sort Antithrombotic treatment in chronic heart failure and sinus rhythm : systematic review
author Caldeira, Daniel
author_facet Caldeira, Daniel
Cruz, Inês
Calé, Rita
Martins, Cristina
Pereira, Hélder
Ferreira, Joaquim J
Pinto, Fausto J.
Costa, João
author_role author
author2 Cruz, Inês
Calé, Rita
Martins, Cristina
Pereira, Hélder
Ferreira, Joaquim J
Pinto, Fausto J.
Costa, João
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Caldeira, Daniel
Cruz, Inês
Calé, Rita
Martins, Cristina
Pereira, Hélder
Ferreira, Joaquim J
Pinto, Fausto J.
Costa, João
dc.subject.por.fl_str_mv Heart failure
Sinus rhythm
Platelet aggregation inhibitors
Anticoagulants
topic Heart failure
Sinus rhythm
Platelet aggregation inhibitors
Anticoagulants
description © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2018-07-27T14:24:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/34378
url http://hdl.handle.net/10451/34378
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv World J Meta-Anal 2015 February 26; 3(1): 36-42
2308-3840
10.13105/wjma.v3.i1.36
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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