Advanced Methods for Natural Products Discovery

Bibliographic Details
Main Author: Gaudêncio, Susana P.
Publication Date: 2023
Other Authors: Bayram, Engin, Lukić Bilela, Lada, Cueto, Mercedes, Díaz-Marrero, Ana R., Haznedaroglu, Berat Z., Jimenez, Carlos, Mandalakis, Manolis, Pereira, Florbela, Reyes, Fernando, Tasdemir, Deniz
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/153864
Summary: Funding Information: This publication is based upon work from COST Action CA18238 (Ocean4Biotech), funded by the European Cooperation in Science and Technology (COST) Program in the period 2019–2023. SPG: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. LLB: The publication is part of a project that has received funding from the Erasmus + Project No. ECOBIAS_609967-EPP-1-2019-1-RS-EPPKA2-CBHE-JP; GA.2019-1991/001-001. Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans HEIs/ECOBIAS. CJ: This work was supported by grants PID2021-122732OB-C22 from MCIN/AEI/10.13039/501100011033/FEDER “A way to make Europe” (AEI, Spanish State Agency for Research and FEDER Programme from the European Union) and RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, co-funded by the FEDER Programme from the European Union, and BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP). FP: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., for an Assistant Research Position (CEECIND/01649/2021). MC: INTERREG-MAC2/1.1b/279 (AHIDAGRO) and the Ministerio de Ciencia e Innovación (Spain) (grant PID2020-115979RR-C32). ARDM is supported with funds from Proyecto Intramural Especial CSIC [Ref. 202280I032]. Publisher Copyright: © 2023 by the authors.
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spelling Advanced Methods for Natural Products DiscoveryBioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidationblue biotechnologycomputer assisted structure elucidation (CASE)dereplicationGlobal Natural Product Social Molecular Networking (GNPS)high throughput next-generation sequencing (HT/NGS)high-throughput screening (HTS)informatic chemometricsmode of action (MoA)molecular networkingnatural productsnatural products databasesrelative and absolute configuration determination in structure elucidationPharmaceutical ScienceDrug DiscoveryPharmacology, Toxicology and Pharmaceutics (miscellaneous)Funding Information: This publication is based upon work from COST Action CA18238 (Ocean4Biotech), funded by the European Cooperation in Science and Technology (COST) Program in the period 2019–2023. SPG: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. LLB: The publication is part of a project that has received funding from the Erasmus + Project No. ECOBIAS_609967-EPP-1-2019-1-RS-EPPKA2-CBHE-JP; GA.2019-1991/001-001. Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans HEIs/ECOBIAS. CJ: This work was supported by grants PID2021-122732OB-C22 from MCIN/AEI/10.13039/501100011033/FEDER “A way to make Europe” (AEI, Spanish State Agency for Research and FEDER Programme from the European Union) and RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, co-funded by the FEDER Programme from the European Union, and BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP). FP: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., for an Assistant Research Position (CEECIND/01649/2021). MC: INTERREG-MAC2/1.1b/279 (AHIDAGRO) and the Ministerio de Ciencia e Innovación (Spain) (grant PID2020-115979RR-C32). ARDM is supported with funds from Proyecto Intramural Especial CSIC [Ref. 202280I032]. Publisher Copyright: © 2023 by the authors.Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known compounds) and structure elucidation, particularly the determination of the absolute configuration of metabolites with stereogenic centers. This review comprehensively focuses on recent technological and instrumental advances, highlighting the development of methods that alleviate these obstacles, paving the way for accelerating NP discovery towards biotechnological applications. Herein, we emphasize the most innovative high-throughput tools and methods for advancing bioactivity screening, NP chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, and three-dimensional NP structure elucidation.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaLAQV@REQUIMTERUNGaudêncio, Susana P.Bayram, EnginLukić Bilela, LadaCueto, MercedesDíaz-Marrero, Ana R.Haznedaroglu, Berat Z.Jimenez, CarlosMandalakis, ManolisPereira, FlorbelaReyes, FernandoTasdemir, Deniz2023-06-12T22:20:04Z2023-05-192023-05-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other66application/pdfhttp://hdl.handle.net/10362/153864eng1660-3397PURE: 63548778https://doi.org/10.3390/md21050308info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:12:02Zoai:run.unl.pt:10362/153864Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:42:25.682493Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Advanced Methods for Natural Products Discovery
Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation
title Advanced Methods for Natural Products Discovery
spellingShingle Advanced Methods for Natural Products Discovery
Gaudêncio, Susana P.
blue biotechnology
computer assisted structure elucidation (CASE)
dereplication
Global Natural Product Social Molecular Networking (GNPS)
high throughput next-generation sequencing (HT/NGS)
high-throughput screening (HTS)
informatic chemometrics
mode of action (MoA)
molecular networking
natural products
natural products databases
relative and absolute configuration determination in structure elucidation
Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
title_short Advanced Methods for Natural Products Discovery
title_full Advanced Methods for Natural Products Discovery
title_fullStr Advanced Methods for Natural Products Discovery
title_full_unstemmed Advanced Methods for Natural Products Discovery
title_sort Advanced Methods for Natural Products Discovery
author Gaudêncio, Susana P.
author_facet Gaudêncio, Susana P.
Bayram, Engin
Lukić Bilela, Lada
Cueto, Mercedes
Díaz-Marrero, Ana R.
Haznedaroglu, Berat Z.
Jimenez, Carlos
Mandalakis, Manolis
Pereira, Florbela
Reyes, Fernando
Tasdemir, Deniz
author_role author
author2 Bayram, Engin
Lukić Bilela, Lada
Cueto, Mercedes
Díaz-Marrero, Ana R.
Haznedaroglu, Berat Z.
Jimenez, Carlos
Mandalakis, Manolis
Pereira, Florbela
Reyes, Fernando
Tasdemir, Deniz
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Gaudêncio, Susana P.
Bayram, Engin
Lukić Bilela, Lada
Cueto, Mercedes
Díaz-Marrero, Ana R.
Haznedaroglu, Berat Z.
Jimenez, Carlos
Mandalakis, Manolis
Pereira, Florbela
Reyes, Fernando
Tasdemir, Deniz
dc.subject.por.fl_str_mv blue biotechnology
computer assisted structure elucidation (CASE)
dereplication
Global Natural Product Social Molecular Networking (GNPS)
high throughput next-generation sequencing (HT/NGS)
high-throughput screening (HTS)
informatic chemometrics
mode of action (MoA)
molecular networking
natural products
natural products databases
relative and absolute configuration determination in structure elucidation
Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
topic blue biotechnology
computer assisted structure elucidation (CASE)
dereplication
Global Natural Product Social Molecular Networking (GNPS)
high throughput next-generation sequencing (HT/NGS)
high-throughput screening (HTS)
informatic chemometrics
mode of action (MoA)
molecular networking
natural products
natural products databases
relative and absolute configuration determination in structure elucidation
Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
description Funding Information: This publication is based upon work from COST Action CA18238 (Ocean4Biotech), funded by the European Cooperation in Science and Technology (COST) Program in the period 2019–2023. SPG: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. LLB: The publication is part of a project that has received funding from the Erasmus + Project No. ECOBIAS_609967-EPP-1-2019-1-RS-EPPKA2-CBHE-JP; GA.2019-1991/001-001. Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans HEIs/ECOBIAS. CJ: This work was supported by grants PID2021-122732OB-C22 from MCIN/AEI/10.13039/501100011033/FEDER “A way to make Europe” (AEI, Spanish State Agency for Research and FEDER Programme from the European Union) and RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, co-funded by the FEDER Programme from the European Union, and BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP). FP: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., for an Assistant Research Position (CEECIND/01649/2021). MC: INTERREG-MAC2/1.1b/279 (AHIDAGRO) and the Ministerio de Ciencia e Innovación (Spain) (grant PID2020-115979RR-C32). ARDM is supported with funds from Proyecto Intramural Especial CSIC [Ref. 202280I032]. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-12T22:20:04Z
2023-05-19
2023-05-19T00:00:00Z
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PURE: 63548778
https://doi.org/10.3390/md21050308
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