Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents

Bibliographic Details
Main Author: Videira-Silva, Antonio
Publication Date: 2019
Other Authors: Albuquerque, Carolina, Fonseca, Helena
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/44649
Summary: © 2019 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescentsAdolescentsAcanthosis nigricansOverweightHyperinsulinemiaInsulin resistance© 2019 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose: Acanthosis nigricans (AN) is a hyperpigmented dermatosis associated with obesity and insulin resistance (IR). There is no consensus whether AN extension scoring offers added value to the clinical estimation of IR. In this study we aimed to assess and score AN using both a short and an extended version of the scale proposed by Burke et al. and analyze the relationships of both versions with hyperinsulinemia and IR. Methods: We analyzed data from 139 overweight adolescents (body mass index ≥85th percentile) aged 12–18 with (n=67) or without (n=72) AN who were followed at a pediatric obesity clinic. Results: Adolescents with AN had higher levels of insulin (d=0.56, P=0.003) and HOMA-IR (d=0.55, P=0.003) compared to those without. Neither the short nor the extended versions of AN scores explained either hyperinsulinemia (β=1.10, P=0.316; β=1.15, P=0.251) or IR (β=1.07, P=0.422; β=1.10, P=0.374). The presence of AN alone predicted hyperinsulinemia and the presence of IR in 7.3% (β=2.68, P=0.008) and 7.1% (β=2.59, P=0.009) of adolescents, respectively. Conclusion: Screening for AN at the neck and axilla is a noninvasive and cost-effective way to identify asymptomatic overweight adolescents with or at risk of developing IR.AVS is supported by the Portuguese Foundation for Science and Technology (SFRH/BD/130193/2017).Korean Society of Pediatric EndocrinologyRepositório da Universidade de LisboaVideira-Silva, AntonioAlbuquerque, CarolinaFonseca, Helena2020-10-23T13:18:06Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/44649engAnn Pediatr Endocrinol Metab 2019;24:99-1032287-101210.6065/apem.2019.24.2.992287-1292info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:23:18Zoai:repositorio.ulisboa.pt:10451/44649Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:10:56.397531Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
title Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
spellingShingle Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
Videira-Silva, Antonio
Adolescents
Acanthosis nigricans
Overweight
Hyperinsulinemia
Insulin resistance
title_short Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
title_full Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
title_fullStr Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
title_full_unstemmed Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
title_sort Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents
author Videira-Silva, Antonio
author_facet Videira-Silva, Antonio
Albuquerque, Carolina
Fonseca, Helena
author_role author
author2 Albuquerque, Carolina
Fonseca, Helena
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Videira-Silva, Antonio
Albuquerque, Carolina
Fonseca, Helena
dc.subject.por.fl_str_mv Adolescents
Acanthosis nigricans
Overweight
Hyperinsulinemia
Insulin resistance
topic Adolescents
Acanthosis nigricans
Overweight
Hyperinsulinemia
Insulin resistance
description © 2019 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-10-23T13:18:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/44649
url http://hdl.handle.net/10451/44649
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ann Pediatr Endocrinol Metab 2019;24:99-103
2287-1012
10.6065/apem.2019.24.2.99
2287-1292
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Korean Society of Pediatric Endocrinology
publisher.none.fl_str_mv Korean Society of Pediatric Endocrinology
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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