Genetic consequences of antiviral therapy on HIV-1

Bibliographic Details
Main Author: Arenas, M
Publication Date: 2015
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://repositorio-aberto.up.pt/handle/10216/117915
Summary: A variety of enzyme inhibitors have been developed in combating HIV-1, however the fast evolutionary rate of this virus commonly leads to the emergence of resistance mutations that finally allows the mutant virus to survive. This review explores the main genetic consequences of HIV-1 molecular evolution during antiviral therapies, including the viral genetic diversity and molecular adaptation. The role of recombination in the generation of drug resistance is also analyzed. Besides the investigation and discussion of published works, an evolutionary analysis of protease-coding genes collected from patients before and after treatment with different protease inhibitors was included to validate previous studies. Finally, the review discusses the importance of considering genetic consequences of antiviral therapies in models of HIV-1 evolution that could improve current genotypic resistance testing and treatments design.
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spelling Genetic consequences of antiviral therapy on HIV-1Acquired Immunodeficiency Syndrome/drug therapyAnti-HIV Agents/therapeutic useAntiretroviral Therapy, Highly ActiveComputational BiologyComputer SimulationDNA, Viral/geneticsDrug Resistance, ViralEvolution, MolecularGenes, Viral/drug effectsGenetic VariationGenotypeHIV Infections/drug therapyHIV-1/drug effectsHIV-1/geneticsHumansMutationPeptide Hydrolases/geneticsRecombination, GeneticVirus ReplicationA variety of enzyme inhibitors have been developed in combating HIV-1, however the fast evolutionary rate of this virus commonly leads to the emergence of resistance mutations that finally allows the mutant virus to survive. This review explores the main genetic consequences of HIV-1 molecular evolution during antiviral therapies, including the viral genetic diversity and molecular adaptation. The role of recombination in the generation of drug resistance is also analyzed. Besides the investigation and discussion of published works, an evolutionary analysis of protease-coding genes collected from patients before and after treatment with different protease inhibitors was included to validate previous studies. Finally, the review discusses the importance of considering genetic consequences of antiviral therapies in models of HIV-1 evolution that could improve current genotypic resistance testing and treatments design.Hindawi20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/117915eng1748-670X10.1155/2015/395826Arenas, Minfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T17:40:13Zoai:repositorio-aberto.up.pt:10216/117915Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T22:22:36.296689Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Genetic consequences of antiviral therapy on HIV-1
title Genetic consequences of antiviral therapy on HIV-1
spellingShingle Genetic consequences of antiviral therapy on HIV-1
Arenas, M
Acquired Immunodeficiency Syndrome/drug therapy
Anti-HIV Agents/therapeutic use
Antiretroviral Therapy, Highly Active
Computational Biology
Computer Simulation
DNA, Viral/genetics
Drug Resistance, Viral
Evolution, Molecular
Genes, Viral/drug effects
Genetic Variation
Genotype
HIV Infections/drug therapy
HIV-1/drug effects
HIV-1/genetics
Humans
Mutation
Peptide Hydrolases/genetics
Recombination, Genetic
Virus Replication
title_short Genetic consequences of antiviral therapy on HIV-1
title_full Genetic consequences of antiviral therapy on HIV-1
title_fullStr Genetic consequences of antiviral therapy on HIV-1
title_full_unstemmed Genetic consequences of antiviral therapy on HIV-1
title_sort Genetic consequences of antiviral therapy on HIV-1
author Arenas, M
author_facet Arenas, M
author_role author
dc.contributor.author.fl_str_mv Arenas, M
dc.subject.por.fl_str_mv Acquired Immunodeficiency Syndrome/drug therapy
Anti-HIV Agents/therapeutic use
Antiretroviral Therapy, Highly Active
Computational Biology
Computer Simulation
DNA, Viral/genetics
Drug Resistance, Viral
Evolution, Molecular
Genes, Viral/drug effects
Genetic Variation
Genotype
HIV Infections/drug therapy
HIV-1/drug effects
HIV-1/genetics
Humans
Mutation
Peptide Hydrolases/genetics
Recombination, Genetic
Virus Replication
topic Acquired Immunodeficiency Syndrome/drug therapy
Anti-HIV Agents/therapeutic use
Antiretroviral Therapy, Highly Active
Computational Biology
Computer Simulation
DNA, Viral/genetics
Drug Resistance, Viral
Evolution, Molecular
Genes, Viral/drug effects
Genetic Variation
Genotype
HIV Infections/drug therapy
HIV-1/drug effects
HIV-1/genetics
Humans
Mutation
Peptide Hydrolases/genetics
Recombination, Genetic
Virus Replication
description A variety of enzyme inhibitors have been developed in combating HIV-1, however the fast evolutionary rate of this virus commonly leads to the emergence of resistance mutations that finally allows the mutant virus to survive. This review explores the main genetic consequences of HIV-1 molecular evolution during antiviral therapies, including the viral genetic diversity and molecular adaptation. The role of recombination in the generation of drug resistance is also analyzed. Besides the investigation and discussion of published works, an evolutionary analysis of protease-coding genes collected from patients before and after treatment with different protease inhibitors was included to validate previous studies. Finally, the review discusses the importance of considering genetic consequences of antiviral therapies in models of HIV-1 evolution that could improve current genotypic resistance testing and treatments design.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/117915
url https://repositorio-aberto.up.pt/handle/10216/117915
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1748-670X
10.1155/2015/395826
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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