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Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles

Bibliographic Details
Main Author: Tavares, Catarina
Publication Date: 2024
Other Authors: Vieira, Tânia, Silva, Jorge C., Borges, João P. M. R., Lança, M. Carmo
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/166758
Summary: Publisher Copyright: © 2024 by the authors. This work was financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the projects LA/P/0037/202 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3
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spelling Bioactive Hydroxyapatite Aerogels with Piezoelectric Particlesaerogelbarium titanatebioactivityhydroxyapatitepiezoelectricitysolvothermal synthesisBiotechnologyBioengineeringBiomaterialsBiochemistryBiomedical EngineeringMolecular MedicinePublisher Copyright: © 2024 by the authors. This work was financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the projects LA/P/0037/202 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3Open-cell foams based on hydroxyapatite (HAp) can mimic the extracellular matrix (ECM) to better replace damaged hard tissues and assist in their regeneration processes. Aerogels of HAp nanowires (NW) with barium titanate (BT) particles were produced and characterized regarding their physical and chemical properties, bioactivity, and in vitro cytotoxicity. Considering the role of piezoelectricity (mainly due to collagen) and surface charges in bone remodeling, all BT particles, of size 280 nm and 2 and 3 µm, contained BaTiO3 in their piezoelectric tetragonal phase. The synthesized nanowires were verified to be AB-type carbonated hydroxyapatite. The aerogels showed high porosity and relatively homogeneous distribution of the BT particles. Barium titanate proved to be non-cytotoxic while all the aerogels produced were cytotoxic for an extract concentration of 1 mg/mL but became non-cytotoxic at concentrations of 0.5 mg/mL and below. It is possible that these results were affected by the higher surface area and quicker dissolution rate of the aerogels. In the bioactivity assays, SEM/EDS, it was not easy to differentiate between the apatite deposition and the surface of the HAp wires. However, a quantitative EDS analysis shows a possible CaP deposition/dissolution cycle taking place.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DF – Departamento de FísicaRUNTavares, CatarinaVieira, TâniaSilva, Jorge C.Borges, João P. M. R.Lança, M. Carmo2024-04-30T01:48:46Z2024-02-272024-02-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/166758eng2313-7673PURE: 87107599https://doi.org/10.3390/biomimetics9030143info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-07-08T01:33:39Zoai:run.unl.pt:10362/166758Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:51:42.247922Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
title Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
spellingShingle Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
Tavares, Catarina
aerogel
barium titanate
bioactivity
hydroxyapatite
piezoelectricity
solvothermal synthesis
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
title_short Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
title_full Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
title_fullStr Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
title_full_unstemmed Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
title_sort Bioactive Hydroxyapatite Aerogels with Piezoelectric Particles
author Tavares, Catarina
author_facet Tavares, Catarina
Vieira, Tânia
Silva, Jorge C.
Borges, João P. M. R.
Lança, M. Carmo
author_role author
author2 Vieira, Tânia
Silva, Jorge C.
Borges, João P. M. R.
Lança, M. Carmo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Tavares, Catarina
Vieira, Tânia
Silva, Jorge C.
Borges, João P. M. R.
Lança, M. Carmo
dc.subject.por.fl_str_mv aerogel
barium titanate
bioactivity
hydroxyapatite
piezoelectricity
solvothermal synthesis
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
topic aerogel
barium titanate
bioactivity
hydroxyapatite
piezoelectricity
solvothermal synthesis
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
description Publisher Copyright: © 2024 by the authors. This work was financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the projects LA/P/0037/202 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3
publishDate 2024
dc.date.none.fl_str_mv 2024-04-30T01:48:46Z
2024-02-27
2024-02-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/166758
url http://hdl.handle.net/10362/166758
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2313-7673
PURE: 87107599
https://doi.org/10.3390/biomimetics9030143
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833597015408246784

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