Correlation of cyto-histological findings in a patient with carcinosarcoma

Bibliographic Details
Main Author: Fava, A
Publication Date: 2023
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://doi.org/10.26537/citotech.vi7.4928
Summary: The study shows a case of a 74 years-old woman, whose only clinical data was suspicion of carcinosarcoma. An exfoliative cytology and biopsy were performed and sent to laboratory for study. Cytology showed atypical cells with arrangement in “moruloid” groups, cytoplasmic vacuolization and marked nuclear pleomorphism. Similar observations were found with biopsy.Immunohistochemical studies were positive for Cytokeratin 7, PAX 8, Vimentin, CD 10, Desmin and p53. Cytological, histological and immunohistochemical findings were compatible with diagnosis of Carcinosarcoma (Malignant Mixed Müllerian Tumor). This neoplasm is very rare, it usually occurs in postmenopausal women, causing bleeding and abdominal pain, and its treatment is chemotherapy and radical hysterectomy.
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spelling Correlation of cyto-histological findings in a patient with carcinosarcomaCorrelação de achados cito-histológicos em pacientes com carcinossarcomacarcinossarcomaneoplasiaatipia celulacélulas glandularescarcinosarcomaneoplasiaatypiaglandular cellsThe study shows a case of a 74 years-old woman, whose only clinical data was suspicion of carcinosarcoma. An exfoliative cytology and biopsy were performed and sent to laboratory for study. Cytology showed atypical cells with arrangement in “moruloid” groups, cytoplasmic vacuolization and marked nuclear pleomorphism. Similar observations were found with biopsy.Immunohistochemical studies were positive for Cytokeratin 7, PAX 8, Vimentin, CD 10, Desmin and p53. Cytological, histological and immunohistochemical findings were compatible with diagnosis of Carcinosarcoma (Malignant Mixed Müllerian Tumor). This neoplasm is very rare, it usually occurs in postmenopausal women, causing bleeding and abdominal pain, and its treatment is chemotherapy and radical hysterectomy.O presente estudo descreve o caso de uma mulher de 74 anos, cujos únicos dados clínicos eram a suspeita de carcinossarcoma. Foram realizadas e enviadas para estudo laboratorial uma citologia esfoliativa e uma biópsia endometrial. A citologia mostrou células atípicas com arranjo em grupos morulares, vacuolização citoplasmática e pleomorfismo nuclear marcado. Na avaliação histológica da biópsia foram encontradas alterações morfológicas semelhantes. O estudo imunohistoquímico mostrou resultados positivos para Citokeratina 7, PAX 8, Vimentina, CD10, Desmina e p53. Assim, os achados citológicos, histológicos e imunohistoquímicos revelaram-se compatíveis com o diagnóstico de carcinossarcoma (tumor Mülleriano misto maligno). Esta neoplasia rara geralmente ocorre em mulheres em pós-menopausa, causando hemorragias frequentes e dor abdominal. O tratamento mais indicado inclui a quimioterapia e a histerectomia radical.Escola de Superior de Saúde | Instituto Politécnico do Porto2023-01-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.26537/citotech.vi7.4928https://doi.org/10.26537/citotech.vi7.4928Citotech Online - Case Review; No. 7 (2022): Citotech Online – Case Review; 20Citotech Online - Case Review; N.º 7 (2022): Citotech Online – Case Review; 202183-735Xreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttps://parc.ipp.pt/index.php/citotech/article/view/4928https://parc.ipp.pt/index.php/citotech/article/view/4928/2620Fava, Ainfo:eu-repo/semantics/openAccess2023-01-22T09:30:14Zoai:oai.parc.ipp.pt:article/4928Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T10:51:03.237461Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Correlation of cyto-histological findings in a patient with carcinosarcoma
Correlação de achados cito-histológicos em pacientes com carcinossarcoma
title Correlation of cyto-histological findings in a patient with carcinosarcoma
spellingShingle Correlation of cyto-histological findings in a patient with carcinosarcoma
Fava, A
carcinossarcoma
neoplasia
atipia celula
células glandulares
carcinosarcoma
neoplasia
atypia
glandular cells
title_short Correlation of cyto-histological findings in a patient with carcinosarcoma
title_full Correlation of cyto-histological findings in a patient with carcinosarcoma
title_fullStr Correlation of cyto-histological findings in a patient with carcinosarcoma
title_full_unstemmed Correlation of cyto-histological findings in a patient with carcinosarcoma
title_sort Correlation of cyto-histological findings in a patient with carcinosarcoma
author Fava, A
author_facet Fava, A
author_role author
dc.contributor.author.fl_str_mv Fava, A
dc.subject.por.fl_str_mv carcinossarcoma
neoplasia
atipia celula
células glandulares
carcinosarcoma
neoplasia
atypia
glandular cells
topic carcinossarcoma
neoplasia
atipia celula
células glandulares
carcinosarcoma
neoplasia
atypia
glandular cells
description The study shows a case of a 74 years-old woman, whose only clinical data was suspicion of carcinosarcoma. An exfoliative cytology and biopsy were performed and sent to laboratory for study. Cytology showed atypical cells with arrangement in “moruloid” groups, cytoplasmic vacuolization and marked nuclear pleomorphism. Similar observations were found with biopsy.Immunohistochemical studies were positive for Cytokeratin 7, PAX 8, Vimentin, CD 10, Desmin and p53. Cytological, histological and immunohistochemical findings were compatible with diagnosis of Carcinosarcoma (Malignant Mixed Müllerian Tumor). This neoplasm is very rare, it usually occurs in postmenopausal women, causing bleeding and abdominal pain, and its treatment is chemotherapy and radical hysterectomy.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-18
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.26537/citotech.vi7.4928
https://doi.org/10.26537/citotech.vi7.4928
url https://doi.org/10.26537/citotech.vi7.4928
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://parc.ipp.pt/index.php/citotech/article/view/4928
https://parc.ipp.pt/index.php/citotech/article/view/4928/2620
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Escola de Superior de Saúde | Instituto Politécnico do Porto
publisher.none.fl_str_mv Escola de Superior de Saúde | Instituto Politécnico do Porto
dc.source.none.fl_str_mv Citotech Online - Case Review; No. 7 (2022): Citotech Online – Case Review; 20
Citotech Online - Case Review; N.º 7 (2022): Citotech Online – Case Review; 20
2183-735X
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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