Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R

Detalhes bibliográficos
Autor(a) principal: Jackson, Carlayne
Data de Publicação: 2018
Outros Autores: Carvalho, Mamede, Genge, Angela, Heiman-Patterson, Terry, Shefner, Jeremy M., Wei, Jenny, Wolff, Andrew A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10451/54325
Resumo: © 2018 University of Texas Health Science Center at San Antonio. Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
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spelling Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-RALSDisease progressionRespiratory functionVital capacity© 2018 University of Texas Health Science Center at San Antonio. Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.Objective: As declining respiratory muscle function commonly leads to disability and death in amyotrophic lateral sclerosis (ALS), respiratory measurements such as slow vital capacity (SVC) may predict disease progression. This study evaluated the relationship between SVC and symptoms measured by the revised ALS Functional Rating Scale (ALSFRS-R). Methods: About 453 ALS placebo-treated patients from the EMPOWER trial (NCT01281189) were evaluated. Correlations between %predicted SVC and individual respiratory ALSFRS-R subdomain items, respiratory subdomain score (maximum score of 12), and total ALSFRS-R score (maximum score of 48) were evaluated using the Pearson correlation coefficient. Pearson's chi-squared test was used to evaluate changes from baseline to week 48 in ALSFRS-R respiratory symptom and respiratory subdomain scores in patients with baseline %predicted SVC above/below the median at baseline and with more slowly/more rapidly decreasing %predicted SVC. Results: The %predicted SVC showed significant correlations with dyspnea, orthopnoea, respiratory insufficiency, respiratory subdomain score, and total ALSFRS-R score (all p < 0.0001). Patients with baseline SVC values < median were significantly more likely than those with baseline SVC ≥ median to have a change in total ALSFRS-R respiratory subdomain score from 12 to <12 (40.9% vs. 30.2%, p = 0.0358) and from ≥10 to <10 (41.6% vs. 24.4%, p = 0.0005). Additionally, patients with smaller declines in SVC over time were significantly more likely to have smaller decreases in their respiratory subdomain scores (p < 0.0001). Conclusions: The higher correlation between %predicted SVC and specific ALSFRS-R symptom scores in patients with rapidly versus more slowly progressing disease reinforces the importance of continually monitoring respiratory function throughout the disease course.Taylor & FrancisRepositório da Universidade de LisboaJackson, CarlayneCarvalho, MamedeGenge, AngelaHeiman-Patterson, TerryShefner, Jeremy M.Wei, JennyWolff, Andrew A.2022-09-06T10:57:21Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54325engAmyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):506-5122167-842110.1080/21678421.2018.14976582167-9223info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:48:04Zoai:repositorio.ulisboa.pt:10451/54325Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:25:08.621522Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
title Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
spellingShingle Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
Jackson, Carlayne
ALS
Disease progression
Respiratory function
Vital capacity
title_short Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
title_full Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
title_fullStr Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
title_full_unstemmed Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
title_sort Relationships between slow vital capacity and measures of respiratory function on the ALSFRS-R
author Jackson, Carlayne
author_facet Jackson, Carlayne
Carvalho, Mamede
Genge, Angela
Heiman-Patterson, Terry
Shefner, Jeremy M.
Wei, Jenny
Wolff, Andrew A.
author_role author
author2 Carvalho, Mamede
Genge, Angela
Heiman-Patterson, Terry
Shefner, Jeremy M.
Wei, Jenny
Wolff, Andrew A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Jackson, Carlayne
Carvalho, Mamede
Genge, Angela
Heiman-Patterson, Terry
Shefner, Jeremy M.
Wei, Jenny
Wolff, Andrew A.
dc.subject.por.fl_str_mv ALS
Disease progression
Respiratory function
Vital capacity
topic ALS
Disease progression
Respiratory function
Vital capacity
description © 2018 University of Texas Health Science Center at San Antonio. Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2022-09-06T10:57:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54325
url http://hdl.handle.net/10451/54325
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):506-512
2167-8421
10.1080/21678421.2018.1497658
2167-9223
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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