Carbon Monoxide modulation of neuronal differentiation

Detalhes bibliográficos
Autor(a) principal: Almeida, Ana Sofia Cabral e Sousa de
Data de Publicação: 2016
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/56700
Resumo: Several evidences support carbon monoxide (CO) for modulating cellular differentiation, in particular for neuronal cells. First, there are some reported studies documenting the biogenesis of mitochondria during spontaneous cell differentiation and it was demonstrated that CO promotes mitochondrial biogenesis. Secondly, ROS are signalling molecules in CO-induced pathways and are also key-players in neuronal differentiation. Third, CO has been described as anti-proliferative molecule in different cell types, namely smooth muscle, cancer and T cells, which can be involved in the balance between differentiation and proliferation that occurs during neurogenesis. Therefore, CO presents a strong potential for modulating neuronal differentiation, opening windows for the development of novel cell therapy strategies for neurological disorders.(...)
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spelling Carbon Monoxide modulation of neuronal differentiationneuronal differentiationcarbon monoxideBiologySeveral evidences support carbon monoxide (CO) for modulating cellular differentiation, in particular for neuronal cells. First, there are some reported studies documenting the biogenesis of mitochondria during spontaneous cell differentiation and it was demonstrated that CO promotes mitochondrial biogenesis. Secondly, ROS are signalling molecules in CO-induced pathways and are also key-players in neuronal differentiation. Third, CO has been described as anti-proliferative molecule in different cell types, namely smooth muscle, cancer and T cells, which can be involved in the balance between differentiation and proliferation that occurs during neurogenesis. Therefore, CO presents a strong potential for modulating neuronal differentiation, opening windows for the development of novel cell therapy strategies for neurological disorders.(...)Vieira, Helena Luísa AraújoRUNAlmeida, Ana Sofia Cabral e Sousa de2019-01-07T18:23:22Z20162016-112016-01-01T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10362/56700enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:36:21Zoai:run.unl.pt:10362/56700Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:07:18.268475Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Carbon Monoxide modulation of neuronal differentiation
title Carbon Monoxide modulation of neuronal differentiation
spellingShingle Carbon Monoxide modulation of neuronal differentiation
Almeida, Ana Sofia Cabral e Sousa de
neuronal differentiation
carbon monoxide
Biology
title_short Carbon Monoxide modulation of neuronal differentiation
title_full Carbon Monoxide modulation of neuronal differentiation
title_fullStr Carbon Monoxide modulation of neuronal differentiation
title_full_unstemmed Carbon Monoxide modulation of neuronal differentiation
title_sort Carbon Monoxide modulation of neuronal differentiation
author Almeida, Ana Sofia Cabral e Sousa de
author_facet Almeida, Ana Sofia Cabral e Sousa de
author_role author
dc.contributor.none.fl_str_mv Vieira, Helena Luísa Araújo
RUN
dc.contributor.author.fl_str_mv Almeida, Ana Sofia Cabral e Sousa de
dc.subject.por.fl_str_mv neuronal differentiation
carbon monoxide
Biology
topic neuronal differentiation
carbon monoxide
Biology
description Several evidences support carbon monoxide (CO) for modulating cellular differentiation, in particular for neuronal cells. First, there are some reported studies documenting the biogenesis of mitochondria during spontaneous cell differentiation and it was demonstrated that CO promotes mitochondrial biogenesis. Secondly, ROS are signalling molecules in CO-induced pathways and are also key-players in neuronal differentiation. Third, CO has been described as anti-proliferative molecule in different cell types, namely smooth muscle, cancer and T cells, which can be involved in the balance between differentiation and proliferation that occurs during neurogenesis. Therefore, CO presents a strong potential for modulating neuronal differentiation, opening windows for the development of novel cell therapy strategies for neurological disorders.(...)
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-11
2016-01-01T00:00:00Z
2019-01-07T18:23:22Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/56700
url http://hdl.handle.net/10362/56700
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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