Advanced Stage Hepatocellular Carcinoma with Multiple Metastasis and Vascular Thrombosis: A Case of Complete Response to Sorafenib

• Main Author: Simão, Adélia
• Publication Date: 2016
• Other Authors: Silva, Raquel, Correia, Lurdes, Alves, Filipe Caseiro, Carvalho, Armando, Costa, J. M. Nascimento
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://hdl.handle.net/10316/108406; https://doi.org/10.20344/amp.6799
• topic: Carcinoma, Hepatocellular/drug therapy; Neoplasm Metastasis; Remission Induction; Sorafenib; Carcinoma Hepatocelular/quimioterapia; Indução de Remissão; Metástase Neoplásica; Sorafenib

Sorafenib is a multi-targeted tyrosine kinase inhibitor, with antiangiogenic and antiproliferative properties, approved for the treatment of advanced hepatocellular carcinoma. It induces a significant increase in the median overall survival, despite a complete response to treatment being rare. We report a clinical case of a 60-year-old male with hepatic cirrhosis, Child-Pugh class A and performance status 0, and advanced hepatocellular carcinoma. The primary tumor measured 17 x 8 cm and had diffuse intrahepatic metastization, extensive lung and left adrenal invasion, as well as thrombosis of inferior vena cava, with projection to the right atrium. This patient showed a rapid and complete response to sorafenib, evaluated by mRECIST (modified Response Evaluation Criteria in Solid Tumors), that remains after three years of treatment.