Blood Pressure Regulation by the Carotid Sinus Nerve
| Main Author: | |
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| Publication Date: | 2022 |
| Other Authors: | , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/132453 |
Summary: | Funding Information: This study was partially supported by the GlaxoSmithKline Bioelectronics R&D ?Innovation Challenge. JS and BM were supported by a contract and a Ph.D. Grant from the Portuguese Foundation for Science and Technology Reference CEECIND/02428/2018 and PD/BD/128336/2017, respectively. This study received funding from the Fundação para a Ciência e Tecnologia (FCT) (UIDB/05704/2020). |
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Blood Pressure Regulation by the Carotid Sinus NerveClinical Implications for Carotid Body Neuromodulationblood pressurecarotid bodycarotid sinus nervehypoxianeuromodulationNeuroscience(all)SDG 3 - Good Health and Well-beingFunding Information: This study was partially supported by the GlaxoSmithKline Bioelectronics R&D ?Innovation Challenge. JS and BM were supported by a contract and a Ph.D. Grant from the Portuguese Foundation for Science and Technology Reference CEECIND/02428/2018 and PD/BD/128336/2017, respectively. This study received funding from the Fundação para a Ciência e Tecnologia (FCT) (UIDB/05704/2020).Chronic carotid sinus nerve (CSN) electrical modulation through kilohertz frequency alternating current improves metabolic control in rat models of type 2 diabetes, underpinning the potential of bioelectronic modulation of the CSN as a therapeutic modality for metabolic diseases in humans. The CSN carries sensory information from the carotid bodies, peripheral chemoreceptor organs that respond to changes in blood biochemical modifications such as hypoxia, hypercapnia, acidosis, and hyperinsulinemia. In addition, the CSN also delivers information from carotid sinus baroreceptors—mechanoreceptor sensory neurons directly involved in the control of blood pressure—to the central nervous system. The interaction between these powerful reflex systems—chemoreflex and baroreflex—whose sensory receptors are in anatomical proximity, may be regarded as a drawback to the development of selective bioelectronic tools to modulate the CSN. Herein we aimed to disclose CSN influence on cardiovascular regulation, particularly under hypoxic conditions, and we tested the hypothesis that neuromodulation of the CSN, either by electrical stimuli or surgical means, does not significantly impact blood pressure. Experiments were performed in Wistar rats aged 10–12 weeks. No significant effects of acute hypoxia were observed in systolic or diastolic blood pressure or heart rate although there was a significant activation of the cardiac sympathetic nervous system. We conclude that chemoreceptor activation by hypoxia leads to an expected increase in sympathetic activity accompanied by compensatory regional mechanisms that assure blood flow to regional beds and maintenance of hemodynamic homeostasis. Upon surgical denervation or electrical block of the CSN, the increase in cardiac sympathetic nervous system activity in response to hypoxia was lost, and there were no significant changes in blood pressure in comparison to control animals. We conclude that the responses to hypoxia and vasomotor control short-term regulation of blood pressure are dissociated in terms of hypoxic response but integrated to generate an effector response to a given change in arterial pressure.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNV Conde, SilviaSacramento, Joana F.Melo, Bernardete F.Fonseca-Pinto, RuiRomero-Ortega, Mario I.Guarino, Maria P.2022-02-07T23:23:12Z2022-01-102022-01-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/132453eng1662-4548PURE: 36488498https://doi.org/10.3389/fnins.2021.725751info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:40:00Zoai:run.unl.pt:10362/132453Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:30:18.081288Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Blood Pressure Regulation by the Carotid Sinus Nerve Clinical Implications for Carotid Body Neuromodulation |
| title |
Blood Pressure Regulation by the Carotid Sinus Nerve |
| spellingShingle |
Blood Pressure Regulation by the Carotid Sinus Nerve V Conde, Silvia blood pressure carotid body carotid sinus nerve hypoxia neuromodulation Neuroscience(all) SDG 3 - Good Health and Well-being |
| title_short |
Blood Pressure Regulation by the Carotid Sinus Nerve |
| title_full |
Blood Pressure Regulation by the Carotid Sinus Nerve |
| title_fullStr |
Blood Pressure Regulation by the Carotid Sinus Nerve |
| title_full_unstemmed |
Blood Pressure Regulation by the Carotid Sinus Nerve |
| title_sort |
Blood Pressure Regulation by the Carotid Sinus Nerve |
| author |
V Conde, Silvia |
| author_facet |
V Conde, Silvia Sacramento, Joana F. Melo, Bernardete F. Fonseca-Pinto, Rui Romero-Ortega, Mario I. Guarino, Maria P. |
| author_role |
author |
| author2 |
Sacramento, Joana F. Melo, Bernardete F. Fonseca-Pinto, Rui Romero-Ortega, Mario I. Guarino, Maria P. |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
V Conde, Silvia Sacramento, Joana F. Melo, Bernardete F. Fonseca-Pinto, Rui Romero-Ortega, Mario I. Guarino, Maria P. |
| dc.subject.por.fl_str_mv |
blood pressure carotid body carotid sinus nerve hypoxia neuromodulation Neuroscience(all) SDG 3 - Good Health and Well-being |
| topic |
blood pressure carotid body carotid sinus nerve hypoxia neuromodulation Neuroscience(all) SDG 3 - Good Health and Well-being |
| description |
Funding Information: This study was partially supported by the GlaxoSmithKline Bioelectronics R&D ?Innovation Challenge. JS and BM were supported by a contract and a Ph.D. Grant from the Portuguese Foundation for Science and Technology Reference CEECIND/02428/2018 and PD/BD/128336/2017, respectively. This study received funding from the Fundação para a Ciência e Tecnologia (FCT) (UIDB/05704/2020). |
| publishDate |
2022 |
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2022-02-07T23:23:12Z 2022-01-10 2022-01-10T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/132453 |
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http://hdl.handle.net/10362/132453 |
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eng |
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eng |
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1662-4548 PURE: 36488498 https://doi.org/10.3389/fnins.2021.725751 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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RCAAP |
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RCAAP |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
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