Natural Killer Cell Receptors and Endometriosis

Bibliographic Details
Main Author: Reis, José Lourenço
Publication Date: 2023
Other Authors: Rosa, Natacha Nurdine, Ângelo-Dias, Miguel, Martins, Catarina, Borrego, Luís Miguel, Lima, Jorge
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/147812
Summary: Funding: This work in the context of the “Women’s Health and Maternal & Fetal Research Group” was partially co-financed by Hospital da Luz Lisboa under the initiative “Luz Investigação”.
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spelling Natural Killer Cell Receptors and EndometriosisA Systematic Reviewectopic endometriumendometriomaendometriosisimmune dysfunctionnatural killer cells (NK cells)NK inhibitionNK receptorsNK suppressionCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding: This work in the context of the “Women’s Health and Maternal & Fetal Research Group” was partially co-financed by Hospital da Luz Lisboa under the initiative “Luz Investigação”.Endometriosis is a chronic inflammatory disorder, characterized by the presence of endometrial cells outside the uterine cavity. An increasing number of studies correlate the immune system with endometriosis, particularly NK receptors (NKR), which have been suggested to play an essential role in the pathogenesis of the disease. This systematic review aims to enlighten the role of NKR in endometriosis. A literature search was performed independently by two reviewers, to identify studies assessing the role of NKR in endometriosis. In total, 18 studies were included. Endometriosis pathogenesis seems to be marked by the overexpression of NK inhibitor receptors (KIRS), namely, CD158a+, KIR2DL1, CD94/NKG2A, PD-1, NKB1, and EB6, and inhibiting ligands such as PD-L1, HLA-E, HLA-G, and HLA-I. Concurrently, there is a decrease in NK-activating receptors and natural cytotoxicity receptors (NCRs), such as NKp46, NKp30, and NKG2D. The immune shift from NK surveillance to NK suppression is also apparent in the greater relative number of ITIM domains compared with ITAM domains in NKRs. In conclusion, NK receptor activity seems to dictate the immunocompetency of women to clear endometriotic cells from the peritoneal cavity. Future research could explore NKRs as therapeutic targets, such as that which is now well established in cancer therapy through immunotherapy.Comprehensive Health Research Centre (CHRC) - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNReis, José LourençoRosa, Natacha NurdineÂngelo-Dias, MiguelMartins, CatarinaBorrego, Luís MiguelLima, Jorge2023-01-18T22:17:10Z2023-012023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/147812eng1422-0067PURE: 50623250https://doi.org/10.3390/ijms24010331info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:08:18Zoai:run.unl.pt:10362/147812Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:45.243375Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Natural Killer Cell Receptors and Endometriosis
A Systematic Review
title Natural Killer Cell Receptors and Endometriosis
spellingShingle Natural Killer Cell Receptors and Endometriosis
Reis, José Lourenço
ectopic endometrium
endometrioma
endometriosis
immune dysfunction
natural killer cells (NK cells)
NK inhibition
NK receptors
NK suppression
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
title_short Natural Killer Cell Receptors and Endometriosis
title_full Natural Killer Cell Receptors and Endometriosis
title_fullStr Natural Killer Cell Receptors and Endometriosis
title_full_unstemmed Natural Killer Cell Receptors and Endometriosis
title_sort Natural Killer Cell Receptors and Endometriosis
author Reis, José Lourenço
author_facet Reis, José Lourenço
Rosa, Natacha Nurdine
Ângelo-Dias, Miguel
Martins, Catarina
Borrego, Luís Miguel
Lima, Jorge
author_role author
author2 Rosa, Natacha Nurdine
Ângelo-Dias, Miguel
Martins, Catarina
Borrego, Luís Miguel
Lima, Jorge
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Comprehensive Health Research Centre (CHRC) - pólo NMS
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Reis, José Lourenço
Rosa, Natacha Nurdine
Ângelo-Dias, Miguel
Martins, Catarina
Borrego, Luís Miguel
Lima, Jorge
dc.subject.por.fl_str_mv ectopic endometrium
endometrioma
endometriosis
immune dysfunction
natural killer cells (NK cells)
NK inhibition
NK receptors
NK suppression
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
topic ectopic endometrium
endometrioma
endometriosis
immune dysfunction
natural killer cells (NK cells)
NK inhibition
NK receptors
NK suppression
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
description Funding: This work in the context of the “Women’s Health and Maternal & Fetal Research Group” was partially co-financed by Hospital da Luz Lisboa under the initiative “Luz Investigação”.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-18T22:17:10Z
2023-01
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/147812
url http://hdl.handle.net/10362/147812
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-0067
PURE: 50623250
https://doi.org/10.3390/ijms24010331
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596857812516864

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