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Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious

Bibliographic Details
Main Author: Messias, A
Publication Date: 2019
Other Authors: Calado, J, Viana, H, Nolasco, F
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.17/3851
Summary: Nephrotic syndrome in a patient with metastatic melanoma can occur in the context of a paraneoplastic glomerulopathy or as a complica tion of treatment. New oncologic immunotherapies, including immune checkpoint inhibitors, have been frequently associated with interstitial nephritis and, in rare cases, with nephrotic syndrome. This article presents the case of a 52 -year -old man diagnosed with metastatic melanoma who was admitted with acute kidney injury and nephrotic syndrome after having started immune checkpoint inhibitors. After investigation, acute kidney injury was attributed to immunotherapy -associated acute interstitial nephritis, and nephrotic syndrome was found to be the result of AA amyloidosis, which is a rare complication of metastatic melanoma.
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spelling Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the ObviousHCC NEFAmyloidosisImmunotherapyMelanomaNephritisNephrotic syndrome in a patient with metastatic melanoma can occur in the context of a paraneoplastic glomerulopathy or as a complica tion of treatment. New oncologic immunotherapies, including immune checkpoint inhibitors, have been frequently associated with interstitial nephritis and, in rare cases, with nephrotic syndrome. This article presents the case of a 52 -year -old man diagnosed with metastatic melanoma who was admitted with acute kidney injury and nephrotic syndrome after having started immune checkpoint inhibitors. After investigation, acute kidney injury was attributed to immunotherapy -associated acute interstitial nephritis, and nephrotic syndrome was found to be the result of AA amyloidosis, which is a rare complication of metastatic melanoma.Sociedade Portuguesa de Nefrologia e HipertensãoRepositório da Unidade Local de Saúde São JoséMessias, ACalado, JViana, HNolasco, F2021-09-20T14:34:32Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3851enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-06T16:50:39Zoai:repositorio.chlc.pt:10400.17/3851Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:21:28.525044Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
spellingShingle Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
Messias, A
HCC NEF
Amyloidosis
Immunotherapy
Melanoma
Nephritis
title_short Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_full Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_fullStr Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_full_unstemmed Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
title_sort Nephrotic Syndrome in a Patient with Metastatic Melanoma: Beyond the Obvious
author Messias, A
author_facet Messias, A
Calado, J
Viana, H
Nolasco, F
author_role author
author2 Calado, J
Viana, H
Nolasco, F
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Unidade Local de Saúde São José
dc.contributor.author.fl_str_mv Messias, A
Calado, J
Viana, H
Nolasco, F
dc.subject.por.fl_str_mv HCC NEF
Amyloidosis
Immunotherapy
Melanoma
Nephritis
topic HCC NEF
Amyloidosis
Immunotherapy
Melanoma
Nephritis
description Nephrotic syndrome in a patient with metastatic melanoma can occur in the context of a paraneoplastic glomerulopathy or as a complica tion of treatment. New oncologic immunotherapies, including immune checkpoint inhibitors, have been frequently associated with interstitial nephritis and, in rare cases, with nephrotic syndrome. This article presents the case of a 52 -year -old man diagnosed with metastatic melanoma who was admitted with acute kidney injury and nephrotic syndrome after having started immune checkpoint inhibitors. After investigation, acute kidney injury was attributed to immunotherapy -associated acute interstitial nephritis, and nephrotic syndrome was found to be the result of AA amyloidosis, which is a rare complication of metastatic melanoma.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-09-20T14:34:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3851
url http://hdl.handle.net/10400.17/3851
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia e Hipertensão
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia e Hipertensão
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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