Pregnancy and its role in breast cancer

Bibliographic Details
Main Author: Martins, Filipe
Publication Date: 2008
Other Authors: Botelho, Maria, Laranjo, Mafalda, Cabrita, António, Torgal, Maria, Oliveira, Carlos de
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/8494
https://doi.org/10.1007/s12156-008-0069-x
Summary: Abstract Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.
id RCAP_b46ae5984b42f2b7f12c02513a3bdbc6
oai_identifier_str oai:estudogeral.uc.pt:10316/8494
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Pregnancy and its role in breast cancerAbstract Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/8494https://hdl.handle.net/10316/8494https://doi.org/10.1007/s12156-008-0069-xengMartins, FilipeBotelho, MariaLaranjo, MafaldaCabrita, AntónioTorgal, MariaOliveira, Carlos deinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2020-05-27T16:14:34Zoai:estudogeral.uc.pt:10316/8494Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:54:50.796935Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Pregnancy and its role in breast cancer
title Pregnancy and its role in breast cancer
spellingShingle Pregnancy and its role in breast cancer
Martins, Filipe
title_short Pregnancy and its role in breast cancer
title_full Pregnancy and its role in breast cancer
title_fullStr Pregnancy and its role in breast cancer
title_full_unstemmed Pregnancy and its role in breast cancer
title_sort Pregnancy and its role in breast cancer
author Martins, Filipe
author_facet Martins, Filipe
Botelho, Maria
Laranjo, Mafalda
Cabrita, António
Torgal, Maria
Oliveira, Carlos de
author_role author
author2 Botelho, Maria
Laranjo, Mafalda
Cabrita, António
Torgal, Maria
Oliveira, Carlos de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Martins, Filipe
Botelho, Maria
Laranjo, Mafalda
Cabrita, António
Torgal, Maria
Oliveira, Carlos de
description Abstract Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/8494
https://hdl.handle.net/10316/8494
https://doi.org/10.1007/s12156-008-0069-x
url https://hdl.handle.net/10316/8494
https://doi.org/10.1007/s12156-008-0069-x
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602190404485120

Similar Items