Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging

Bibliographic Details
Main Author: Sá, Arsénio Vasconcelos
Publication Date: 2010
Other Authors: Matias, Áurea A., Prata, M. Isabel M., Geraldes, Carlos F. G. C., Ferreira, Paula M. T., André, João P.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/14303
Summary: We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.
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spelling Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imagingTriazaOrthogonal protectionBifunctional chelatorsGalliumRadiopharmacyIntegrin αѵβ₃receptorIntegrin alpha(v)beta(3) receptorIntegrin a ß receptor ? 3Integrin α β receptor ν 3Science & TechnologyWe report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.Fundação para a Ciência e a Tecnologia (FCT)ElsevierUniversidade do MinhoSá, Arsénio VasconcelosMatias, Áurea A.Prata, M. Isabel M.Geraldes, Carlos F. G. C.Ferreira, Paula M. T.André, João P.20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/14303eng0960-894X10.1016/j.bmcl.2010.10.05921106453info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T04:15:11Zoai:repositorium.sdum.uminho.pt:1822/14303Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:57:52.776096Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
title Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
spellingShingle Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
Sá, Arsénio Vasconcelos
Triaza
Orthogonal protection
Bifunctional chelators
Gallium
Radiopharmacy
Integrin αѵβ₃receptor
Integrin alpha(v)beta(3) receptor
Integrin a ß receptor ? 3
Integrin α β receptor ν 3
Science & Technology
title_short Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
title_full Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
title_fullStr Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
title_full_unstemmed Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
title_sort Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
author Sá, Arsénio Vasconcelos
author_facet Sá, Arsénio Vasconcelos
Matias, Áurea A.
Prata, M. Isabel M.
Geraldes, Carlos F. G. C.
Ferreira, Paula M. T.
André, João P.
author_role author
author2 Matias, Áurea A.
Prata, M. Isabel M.
Geraldes, Carlos F. G. C.
Ferreira, Paula M. T.
André, João P.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Sá, Arsénio Vasconcelos
Matias, Áurea A.
Prata, M. Isabel M.
Geraldes, Carlos F. G. C.
Ferreira, Paula M. T.
André, João P.
dc.subject.por.fl_str_mv Triaza
Orthogonal protection
Bifunctional chelators
Gallium
Radiopharmacy
Integrin αѵβ₃receptor
Integrin alpha(v)beta(3) receptor
Integrin a ß receptor ? 3
Integrin α β receptor ν 3
Science & Technology
topic Triaza
Orthogonal protection
Bifunctional chelators
Gallium
Radiopharmacy
Integrin αѵβ₃receptor
Integrin alpha(v)beta(3) receptor
Integrin a ß receptor ? 3
Integrin α β receptor ν 3
Science & Technology
description We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/14303
url https://hdl.handle.net/1822/14303
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0960-894X
10.1016/j.bmcl.2010.10.059
21106453
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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