Nanomedicine-based strategies to target and modulate the tumor microenvironment

Bibliographic Details
Main Author: Mendes, Bárbara B.
Publication Date: 2021
Other Authors: Sousa, Diana P., Conniot, João, Conde, João
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/154245
Summary: Funding Information: The authors acknowledge financial support from Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). Funding Information: The authors acknowledge financial support from Funda??o para a Ci?ncia e a Tecnologia/ Minist?rio da Ci?ncia, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). None declared by authors. Publisher Copyright: © 2021 Elsevier Inc.
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spelling Nanomedicine-based strategies to target and modulate the tumor microenvironmentmodulationnanotechnologytargeting, therapytumor microenvironmentOncologyCancer ResearchSDG 3 - Good Health and Well-beingFunding Information: The authors acknowledge financial support from Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). Funding Information: The authors acknowledge financial support from Funda??o para a Ci?ncia e a Tecnologia/ Minist?rio da Ci?ncia, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). None declared by authors. Publisher Copyright: © 2021 Elsevier Inc.The interest in nanomedicine for cancer theranostics has grown significantly over the past few decades. However, these nanomedicines need to overcome several physiological barriers intrinsic to the tumor microenvironment (TME) before reaching their target. Intrinsic tumor genetic/phenotypic variations, along with intratumor heterogeneity, provide different cues to each cancer type, making each patient with cancer unique. This brings additional challenges in translating nanotechnology-based systems into clinically reliable therapies. To develop efficient therapeutic strategies, it is important to understand the dynamic interactions between TME players and the complex mechanisms involved, because they constitute invaluable targets to dismantle tumor progression. In this review, we discuss the latest nanotechnology-based strategies for cancer diagnosis and therapy as well as the potential targets for the design of future anticancer nanomedicines.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNMendes, Bárbara B.Sousa, Diana P.Conniot, JoãoConde, João2023-06-21T22:18:39Z2021-092021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other16application/pdfhttp://hdl.handle.net/10362/154245eng2405-8033PURE: 33428173https://doi.org/10.1016/j.trecan.2021.05.001info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:40:51Zoai:run.unl.pt:10362/154245Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:42:35.868816Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Nanomedicine-based strategies to target and modulate the tumor microenvironment
title Nanomedicine-based strategies to target and modulate the tumor microenvironment
spellingShingle Nanomedicine-based strategies to target and modulate the tumor microenvironment
Mendes, Bárbara B.
modulation
nanotechnology
targeting, therapy
tumor microenvironment
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
title_short Nanomedicine-based strategies to target and modulate the tumor microenvironment
title_full Nanomedicine-based strategies to target and modulate the tumor microenvironment
title_fullStr Nanomedicine-based strategies to target and modulate the tumor microenvironment
title_full_unstemmed Nanomedicine-based strategies to target and modulate the tumor microenvironment
title_sort Nanomedicine-based strategies to target and modulate the tumor microenvironment
author Mendes, Bárbara B.
author_facet Mendes, Bárbara B.
Sousa, Diana P.
Conniot, João
Conde, João
author_role author
author2 Sousa, Diana P.
Conniot, João
Conde, João
author2_role author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centre for Toxicogenomics and Human Health (ToxOmics)
RUN
dc.contributor.author.fl_str_mv Mendes, Bárbara B.
Sousa, Diana P.
Conniot, João
Conde, João
dc.subject.por.fl_str_mv modulation
nanotechnology
targeting, therapy
tumor microenvironment
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
topic modulation
nanotechnology
targeting, therapy
tumor microenvironment
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
description Funding Information: The authors acknowledge financial support from Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). Funding Information: The authors acknowledge financial support from Funda??o para a Ci?ncia e a Tecnologia/ Minist?rio da Ci?ncia, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). None declared by authors. Publisher Copyright: © 2021 Elsevier Inc.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
2021-09-01T00:00:00Z
2023-06-21T22:18:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154245
url http://hdl.handle.net/10362/154245
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2405-8033
PURE: 33428173
https://doi.org/10.1016/j.trecan.2021.05.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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