The role of inflammation in diabetic cardiomyopathy

Bibliographic Details
Main Author: Reis, Flávio
Publication Date: 2012
Other Authors: Nunes, Sara, Soares, Edna, Pereira, Frederico
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10316/109876
https://doi.org/10.2147/IJICMR.S21679
Summary: Type 2 diabetes mellitus (T2DM) is a major risk factor for developing cardiovascular disease and represents a serious public health problem, with high rates of mortality and morbidity worldwide. T2DM etiology is complex and multifactorial and is associated with several complications, including those at myocardium level. Diabetic cardiomyopathy (DCM) is viewed as a specific cardiomyopathy and defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes. T2DM has long been classified as an inflammatory disease and recent studies have identified the importance of the inflammatory process in the development and progression of heart failure. In this review, the authors outline the main mechanisms underlying the potential contribution of the inflammatory process in the development and evolution of DCM. In addition, potential therapeutic strategies against inflammation of DCM are discussed.
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spelling The role of inflammation in diabetic cardiomyopathytype 2 diabetes mellitusinflammationmyocardiuminflammatory processType 2 diabetes mellitus (T2DM) is a major risk factor for developing cardiovascular disease and represents a serious public health problem, with high rates of mortality and morbidity worldwide. T2DM etiology is complex and multifactorial and is associated with several complications, including those at myocardium level. Diabetic cardiomyopathy (DCM) is viewed as a specific cardiomyopathy and defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes. T2DM has long been classified as an inflammatory disease and recent studies have identified the importance of the inflammatory process in the development and progression of heart failure. In this review, the authors outline the main mechanisms underlying the potential contribution of the inflammatory process in the development and evolution of DCM. In addition, potential therapeutic strategies against inflammation of DCM are discussed.Dove Medical Press2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109876http://hdl.handle.net/10316/109876https://doi.org/10.2147/IJICMR.S21679eng1179-139XReis, FlávioNunes, SaraSoares, EdnaPereira, Fredericoinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2023-11-02T12:48:45Zoai:estudogeral.uc.pt:10316/109876Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:01:32.057280Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The role of inflammation in diabetic cardiomyopathy
title The role of inflammation in diabetic cardiomyopathy
spellingShingle The role of inflammation in diabetic cardiomyopathy
Reis, Flávio
type 2 diabetes mellitus
inflammation
myocardium
inflammatory process
title_short The role of inflammation in diabetic cardiomyopathy
title_full The role of inflammation in diabetic cardiomyopathy
title_fullStr The role of inflammation in diabetic cardiomyopathy
title_full_unstemmed The role of inflammation in diabetic cardiomyopathy
title_sort The role of inflammation in diabetic cardiomyopathy
author Reis, Flávio
author_facet Reis, Flávio
Nunes, Sara
Soares, Edna
Pereira, Frederico
author_role author
author2 Nunes, Sara
Soares, Edna
Pereira, Frederico
author2_role author
author
author
dc.contributor.author.fl_str_mv Reis, Flávio
Nunes, Sara
Soares, Edna
Pereira, Frederico
dc.subject.por.fl_str_mv type 2 diabetes mellitus
inflammation
myocardium
inflammatory process
topic type 2 diabetes mellitus
inflammation
myocardium
inflammatory process
description Type 2 diabetes mellitus (T2DM) is a major risk factor for developing cardiovascular disease and represents a serious public health problem, with high rates of mortality and morbidity worldwide. T2DM etiology is complex and multifactorial and is associated with several complications, including those at myocardium level. Diabetic cardiomyopathy (DCM) is viewed as a specific cardiomyopathy and defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes. T2DM has long been classified as an inflammatory disease and recent studies have identified the importance of the inflammatory process in the development and progression of heart failure. In this review, the authors outline the main mechanisms underlying the potential contribution of the inflammatory process in the development and evolution of DCM. In addition, potential therapeutic strategies against inflammation of DCM are discussed.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109876
http://hdl.handle.net/10316/109876
https://doi.org/10.2147/IJICMR.S21679
url http://hdl.handle.net/10316/109876
https://doi.org/10.2147/IJICMR.S21679
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1179-139X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602552034230273

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