Mesalazine induced tubulointersticial nephritis

• Main Author: Campos, A.
• Publication Date: 2015
• Other Authors: Santos, S., Santos, J., Malheiro, J., Lobato, L., Vizcaíno, J., Cabrita, A.
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10400.16/1926
• topic: Inflammatory bowel disease; kidney disease; mesalazine; tubulointersticial nephritis; Doença inflamatória intestinal; doença renal; nefrite tubulointersticial

Inflammatory bowel disease and its various treatments may affect the kidney in several ways tubulointersticial nephritis is a rare but serious complication of longer-term mesalazine use. There are few cases reported in the literature. We report the first two cases of mesalazine-induced tubulointersticial nephritis, recently diagnosed in our department. The first one refers to a patient with ulcerous colitis and the second one to a patient with Crohn’s disease. Then the authors present a review of literature about the renal involvement in the inflammatory bowel disease. New cases of mesalazine nephrotoxicity should be reported to allow more accurate incidence estimation of this serious adverse effect. Routine monitoring of renal function is simple, inexpensive and allows an early diagnosis of this complication