Montelukast and Neuropsychiatric Events in Children: What is the Evidence?

Detalhes bibliográficos
Autor(a) principal: Lima,Raquel
Data de Publicação: 2024
Outros Autores: Moreira,Mafalda Sá, Rocha,Leonor, Carneiro,João Nuno, Azevedo,José Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2184-06282024000400301
Resumo: Abstract Childhood asthma is a prevalent chronic illness, and the medication montelukast is frequently used as treatment. However, this drug has been linked to neuropsychiatric events that have potentially fatal outcomes. The objective of this review paper was to evaluate the available evidence on this association between montelukast and neuropsychiatric events in children. From an analysis of 17 articles and 1 clinical guidance standard identified by a bibliographic search method, only 5 fulfilled the previously defined inclusion criteria. These selected studies provide support for the existence of possible occurrences of montelukast-induced neuropsychiatric symptoms among asthmatic pediatric patients administered with the medication. Therefore, healthcare providers need to be informed about these risks while making prescribing decisions for young patients who are taking montelukast or undergoing follow-up care subsequently. More multicenter studies are needed, with robust samples, longer follow-up period and well-defined methodology, to clarify the association of montelukast with neuropsychiatric events in children.
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spelling Montelukast and Neuropsychiatric Events in Children: What is the Evidence?Anti-Asthmatic Agents/adverse effectsChildMental Disorders/chemically inducedMontelukast/adverse effectsNervous System Diseases/chemically inducedAbstract Childhood asthma is a prevalent chronic illness, and the medication montelukast is frequently used as treatment. However, this drug has been linked to neuropsychiatric events that have potentially fatal outcomes. The objective of this review paper was to evaluate the available evidence on this association between montelukast and neuropsychiatric events in children. From an analysis of 17 articles and 1 clinical guidance standard identified by a bibliographic search method, only 5 fulfilled the previously defined inclusion criteria. These selected studies provide support for the existence of possible occurrences of montelukast-induced neuropsychiatric symptoms among asthmatic pediatric patients administered with the medication. Therefore, healthcare providers need to be informed about these risks while making prescribing decisions for young patients who are taking montelukast or undergoing follow-up care subsequently. More multicenter studies are needed, with robust samples, longer follow-up period and well-defined methodology, to clarify the association of montelukast with neuropsychiatric events in children.Círculo Médico2024-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2184-06282024000400301Gazeta Médica v.11 n.4 2024reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2184-06282024000400301Lima,RaquelMoreira,Mafalda SáRocha,LeonorCarneiro,João NunoAzevedo,José Miguelinfo:eu-repo/semantics/openAccess2025-04-10T23:02:34Zoai:scielo:S2184-06282024000400301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:21:37.903680Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
spellingShingle Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
Lima,Raquel
Anti-Asthmatic Agents/adverse effects
Child
Mental Disorders/chemically induced
Montelukast/adverse effects
Nervous System Diseases/chemically induced
title_short Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_full Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_fullStr Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_full_unstemmed Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_sort Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
author Lima,Raquel
author_facet Lima,Raquel
Moreira,Mafalda Sá
Rocha,Leonor
Carneiro,João Nuno
Azevedo,José Miguel
author_role author
author2 Moreira,Mafalda Sá
Rocha,Leonor
Carneiro,João Nuno
Azevedo,José Miguel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lima,Raquel
Moreira,Mafalda Sá
Rocha,Leonor
Carneiro,João Nuno
Azevedo,José Miguel
dc.subject.por.fl_str_mv Anti-Asthmatic Agents/adverse effects
Child
Mental Disorders/chemically induced
Montelukast/adverse effects
Nervous System Diseases/chemically induced
topic Anti-Asthmatic Agents/adverse effects
Child
Mental Disorders/chemically induced
Montelukast/adverse effects
Nervous System Diseases/chemically induced
description Abstract Childhood asthma is a prevalent chronic illness, and the medication montelukast is frequently used as treatment. However, this drug has been linked to neuropsychiatric events that have potentially fatal outcomes. The objective of this review paper was to evaluate the available evidence on this association between montelukast and neuropsychiatric events in children. From an analysis of 17 articles and 1 clinical guidance standard identified by a bibliographic search method, only 5 fulfilled the previously defined inclusion criteria. These selected studies provide support for the existence of possible occurrences of montelukast-induced neuropsychiatric symptoms among asthmatic pediatric patients administered with the medication. Therefore, healthcare providers need to be informed about these risks while making prescribing decisions for young patients who are taking montelukast or undergoing follow-up care subsequently. More multicenter studies are needed, with robust samples, longer follow-up period and well-defined methodology, to clarify the association of montelukast with neuropsychiatric events in children.
publishDate 2024
dc.date.none.fl_str_mv 2024-12-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S2184-06282024000400301
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S2184-06282024000400301
dc.language.iso.fl_str_mv eng
language eng
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Círculo Médico
publisher.none.fl_str_mv Círculo Médico
dc.source.none.fl_str_mv Gazeta Médica v.11 n.4 2024
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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repository.mail.fl_str_mv info@rcaap.pt
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