Tofacitinib: an Option for Acute Severe Ulcerative Colitis?

Detalhes bibliográficos
Autor(a) principal: Santos, S
Data de Publicação: 2022
Outros Autores: Gamelas, V, Saraiva, R, Simões, G, Saiote, J, Ramos, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10400.17/4895
Resumo: Tofacitinib has emerged as a new option for ulcerative colitis. Its rapid absorption, metabolism, and clinical improvement make it an interesting option for rescue therapy in acute severe ulcerative colitis (ASUC), a situation with limited therapeutic options in patients with a long-term disease course and multiple drug failure. The management of ASUC in this setting becomes challenging, underlying the need for new drugs and data on their efficacy and safety. We describe 2 cases of acute episodes in which tofacitinib was used as a rescue therapy.
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spelling Tofacitinib: an Option for Acute Severe Ulcerative Colitis?Tofacitinib: uma Opção na Colite Ulcerosa Aguda Grave?HSAC GASAcute Severe Ulcerative ColitisTofacitinibTofacitinib has emerged as a new option for ulcerative colitis. Its rapid absorption, metabolism, and clinical improvement make it an interesting option for rescue therapy in acute severe ulcerative colitis (ASUC), a situation with limited therapeutic options in patients with a long-term disease course and multiple drug failure. The management of ASUC in this setting becomes challenging, underlying the need for new drugs and data on their efficacy and safety. We describe 2 cases of acute episodes in which tofacitinib was used as a rescue therapy.KargerRepositório da Unidade Local de Saúde São JoséSantos, SGamelas, VSaraiva, RSimões, GSaiote, JRamos, J2024-05-09T15:31:59Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4895eng10.1159/000514781info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-06T16:49:10Zoai:repositorio.chlc.pt:10400.17/4895Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:20:13.463082Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
Tofacitinib: uma Opção na Colite Ulcerosa Aguda Grave?
title Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
spellingShingle Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
Santos, S
HSAC GAS
Acute Severe Ulcerative Colitis
Tofacitinib
title_short Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
title_full Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
title_fullStr Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
title_full_unstemmed Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
title_sort Tofacitinib: an Option for Acute Severe Ulcerative Colitis?
author Santos, S
author_facet Santos, S
Gamelas, V
Saraiva, R
Simões, G
Saiote, J
Ramos, J
author_role author
author2 Gamelas, V
Saraiva, R
Simões, G
Saiote, J
Ramos, J
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Unidade Local de Saúde São José
dc.contributor.author.fl_str_mv Santos, S
Gamelas, V
Saraiva, R
Simões, G
Saiote, J
Ramos, J
dc.subject.por.fl_str_mv HSAC GAS
Acute Severe Ulcerative Colitis
Tofacitinib
topic HSAC GAS
Acute Severe Ulcerative Colitis
Tofacitinib
description Tofacitinib has emerged as a new option for ulcerative colitis. Its rapid absorption, metabolism, and clinical improvement make it an interesting option for rescue therapy in acute severe ulcerative colitis (ASUC), a situation with limited therapeutic options in patients with a long-term disease course and multiple drug failure. The management of ASUC in this setting becomes challenging, underlying the need for new drugs and data on their efficacy and safety. We describe 2 cases of acute episodes in which tofacitinib was used as a rescue therapy.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2024-05-09T15:31:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4895
url http://hdl.handle.net/10400.17/4895
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1159/000514781
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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