The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
| Main Author: | |
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| Publication Date: | 2018 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10451/45121 |
Summary: | © 2001-2020 Sociedade Portuguesa de Reumatologia |
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The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapyClinical trialDactylitisTreatment algorithmPsoriatic arthritis© 2001-2020 Sociedade Portuguesa de ReumatologiaThe GO-DACT is an investigator-initiated, national, multicentric randomized placebo-controlled double-blinded trial, that assesses dactylitis as primary endpoint. Psoriatic arthritis patients naïve to methotrexate and biologic disease modifying anti-rheumatic drugs, with at least one active dactylitis, were assigned to golimumab in combination with methotrexate or placebo in combination with methotrexate, for 24 weeks. Both clinical (dactylitis severity score and the Leeds dactylitis index) and imaging (high resolution magnetic resonance imaging), among others, were assessed as outcomes. The main objective of GO-DACT is to provide evidence to improve the treatment algorithm and care of psoriatic arthritis patients with active dactylitis. In this manuscript we describe the GO-DACT protocol and general concepts of the methodology of this trial.Sociedade Portuguesa de ReumatologiaRepositório da Universidade de LisboaVieira de Sousa, Elsa CristinaCanhao, HelenaAlves, PedroRodrigues, Ana MariaTeixeira, FilipaTavares-Costa, JoséBernardo, AlexandraPimenta, SofiaPimentel-Santos, FernandoGomes, João LAguiar, RenataVideira, TacianaPinto, PatríciaCatita, CristinaSantos, HelenaBorges, JoanaSequeira, GraçaRibeiro, CéliaTeixeira, LídiaÁvila-Ribeiro, PedroMartins, Fernando MRibeiro, Ruy M.Fonseca, João Eurico2020-12-03T18:00:56Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45121engActa Reumatol Port. 2018 Apr-Jun; 43 (2): 80-920303-464Xinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:25:16Zoai:repositorio.ulisboa.pt:10451/45121Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:11:24.849731Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy |
| title |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy |
| spellingShingle |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy Vieira de Sousa, Elsa Cristina Clinical trial Dactylitis Treatment algorithm Psoriatic arthritis |
| title_short |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy |
| title_full |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy |
| title_fullStr |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy |
| title_full_unstemmed |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy |
| title_sort |
The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy |
| author |
Vieira de Sousa, Elsa Cristina |
| author_facet |
Vieira de Sousa, Elsa Cristina Canhao, Helena Alves, Pedro Rodrigues, Ana Maria Teixeira, Filipa Tavares-Costa, José Bernardo, Alexandra Pimenta, Sofia Pimentel-Santos, Fernando Gomes, João L Aguiar, Renata Videira, Taciana Pinto, Patrícia Catita, Cristina Santos, Helena Borges, Joana Sequeira, Graça Ribeiro, Célia Teixeira, Lídia Ávila-Ribeiro, Pedro Martins, Fernando M Ribeiro, Ruy M. Fonseca, João Eurico |
| author_role |
author |
| author2 |
Canhao, Helena Alves, Pedro Rodrigues, Ana Maria Teixeira, Filipa Tavares-Costa, José Bernardo, Alexandra Pimenta, Sofia Pimentel-Santos, Fernando Gomes, João L Aguiar, Renata Videira, Taciana Pinto, Patrícia Catita, Cristina Santos, Helena Borges, Joana Sequeira, Graça Ribeiro, Célia Teixeira, Lídia Ávila-Ribeiro, Pedro Martins, Fernando M Ribeiro, Ruy M. Fonseca, João Eurico |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Vieira de Sousa, Elsa Cristina Canhao, Helena Alves, Pedro Rodrigues, Ana Maria Teixeira, Filipa Tavares-Costa, José Bernardo, Alexandra Pimenta, Sofia Pimentel-Santos, Fernando Gomes, João L Aguiar, Renata Videira, Taciana Pinto, Patrícia Catita, Cristina Santos, Helena Borges, Joana Sequeira, Graça Ribeiro, Célia Teixeira, Lídia Ávila-Ribeiro, Pedro Martins, Fernando M Ribeiro, Ruy M. Fonseca, João Eurico |
| dc.subject.por.fl_str_mv |
Clinical trial Dactylitis Treatment algorithm Psoriatic arthritis |
| topic |
Clinical trial Dactylitis Treatment algorithm Psoriatic arthritis |
| description |
© 2001-2020 Sociedade Portuguesa de Reumatologia |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2020-12-03T18:00:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/45121 |
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http://hdl.handle.net/10451/45121 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Acta Reumatol Port. 2018 Apr-Jun; 43 (2): 80-92 0303-464X |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Sociedade Portuguesa de Reumatologia |
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Sociedade Portuguesa de Reumatologia |
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